ReviewCold Spring Harbor perspectives in medicine2015
Tuberculosis Comorbidity with Communicable and Noncommunicable Diseases.
Review in Cold Spring Harbor perspectives in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Prevalence and risks of tuberculosis multimorbidity in low-income and middle-income countries: a meta-review.BMJ open · 2022Pooled it
- Association between diabetes mellitus and active tuberculosis in Africa and the effect of HIV.Tropical medicine & international health : TM & IH · 2017Pooled it
- Trial
- Readmission and survival of hospitalized pulmonary tuberculosis patients: a nationwide record-based cohort analysis in Thailand (2017-2022).Infectious diseases of poverty · 2026Article
- Reframing TB Care: A Perspective on Multimorbidity-Centered Care for People with TB.Tropical medicine and infectious disease · 2026Article
- Exploring the role of extreme climate events (ECEs) in the incidence of respiratory disease in South Africa.International journal of biometeorology · 2026Article
- Cell-mediated immune responses of beta-glucan on the pathogenesis of chronic tuberculosis infection.Frontiers in immunology · 2026Review
- Implementation fidelity of tuberculosis screening for Diabetes mellitus patients among healthcare providers offering diabetes services in Ubungo District, Dar es Salaam, Tanzania.PLOS global public health · 2026Article
- Health Research Ethics in Southern Africa: Building Capacity and Cultivating Excellence.Journal of empirical research on human research ethics : JERHRE · 2025Article
- Risk factors for latent tuberculosis infection clustering among the elderly: a population-based cross-sectional study in Eastern China.BMC infectious diseases · 2025Article
- The gut and lung microbiome across the TB disease spectrum.Frontiers in microbiology · 2025Review
- Prevalence and clinical profile of comorbidity among newly diagnosed pulmonary tuberculosis patients: a multi-center observational study in eastern China.Frontiers in medicine · 2025Article
- Comorbidity profiles among sputum-positive tuberculosis patients in Cameroon.Frontiers in tuberculosis · 2024Article
- Risk factors of pulmonary tuberculosis in Indonesia: A case-control study in a high disease prevalence region.Narra J · 2024Article
- Humanized Mouse Models of Bacterial Infections.Antibiotics (Basel, Switzerland) · 2024Review
- Bacteriophage therapy for the treatment of Mycobacterium tuberculosis infections in humanized mice.Communications biology · 2024Article
- Identification and optimization of pyridine carboxamide-based scaffold as a drug lead forAntimicrobial agents and chemotherapy · 2024Article
- Ending tuberculosis: challenges and opportunities.Frontiers in tuberculosis · 2024Review
- Current landscape of exosomes in tuberculosis development, diagnosis, and treatment applications.Frontiers in immunology · 2024Review
- The Use of Particulate Systems for Tuberculosis Prophylaxis and Treatment: Opportunities and Challenges.Microorganisms · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 18th WHO Global Tuberculosis Annual Report indicates that there were an estimated 8.6 million incident cases of tuberculosis (TB) in 2012, which included 2.9 million women and 530,000 children. TB caused 1.3 million deaths including 320,000 human immunodeficiency virus (HIV)-infected people; three-quarters of deaths occurred in Africa and Southeast Asia. With one-third of the world's population latently infected with Mycobacterium tuberculosis (Mtb), active TB disease is primarily associated with a break down in immune surveillance. This explains the strong link between active TB disease and other communicable diseases (CDs) or noncommunicable diseases (NCDs) that exert a toll on the immune system. Comorbid NCD risk factors include diabetes, smoking, malnutrition, and chronic lung disease, all of which have increased relentlessly over the past decade in developing countries. The huge overlap between killer infections such as TB, HIV, malaria, and severe viral infections with NCDs, results in a "double burden of disease" in developing countries. The current focus on vertical disease programs fails to recognize comorbidities or to encourage joint management approaches. This review highlights major disease overlaps and discusses the rationale for better integration of tuberculosis care with services for NCDs and other infectious diseases to enhance the overall efficiency of the public health responses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.