ArticleScientific reports2015
Handedness and the X chromosome: the role of androgen receptor CAG-repeat length.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- A comprehensive scoping review and meta-analysis of upper limb strength asymmetry.Scientific reports · 2025Pooled it
- DNA methylation in peripheral tissues and left-handedness.Scientific reports · 2022Pooled it
- Prenatal Maternal Stress and Weak Handedness in Early Childhood: The Iowa Flood Study.Developmental psychobiology · 2026Article
- Biodevelopmental Correlates of Sexual Orientation in Men: Evidence from a Polish Sample.Archives of sexual behavior · 2025Article
- Carving the Biodevelopment of Same-Sex Sexual Orientation at Its Joints.Archives of sexual behavior · 2023Article
- Handedness and Birth Order Among Heterosexual Men, Gay Men, and Sao Praphet Song in Northern Thailand.Archives of sexual behavior · 2020Article
- Associations of Bisexuality and Homosexuality with Handedness and Footedness: A Latent Variable Analysis Approach.Archives of sexual behavior · 2019Article
- Evidence for distinct biodevelopmental influences on male sexual orientation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The molecular genetics of hand preference revisited.Scientific reports · 2019Article
- Are There Any Biomarkers for Pedophilia and Sexual Child Abuse? A Review.Frontiers in psychiatry · 2019Review
- Building an Asymmetrical Brain: The Molecular Perspective.Frontiers in psychology · 2019Review
- Article
- Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains.Scientific reports · 2018Article
- Triplets, birthweight, and handedness.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Article
- Asymmetric development of the nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries.eLife · 2017Article
- The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses.Frontiers in psychology · 2017Article
- Handedness is a biomarker of variation in anal sex role behavior and Recalled Childhood Gender Nonconformity among gay men.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal androgen exposure has been suggested to be one of the factors influencing handedness, making the androgen receptor gene (AR) a likely candidate gene for individual differences in handedness. Here, we examined the relationship between the length of the CAG-repeat in AR and different handedness phenotypes in a sample of healthy adults of both sexes (n = 1057). Since AR is located on the X chromosome, statistical analyses in women heterozygous for CAG-repeat lengths are complicated by X chromosome inactivation. We thus analyzed a sample of women that were homozygous for the CAG-repeat length (n = 77). Mixed-handedness in men was significantly associated with longer CAG-repeat blocks and women homozygous for longer CAG-repeats showed a tendency for stronger left-handedness. These results suggest that handedness in both sexes is associated with the AR CAG-repeat length, with longer repeats being related to a higher incidence of non-right-handedness. Since longer CAG-repeat blocks have been linked to less efficient AR function, these results implicate that differences in AR signaling in the developing brain might be one of the factors that determine individual differences in brain lateralization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.