ArticleJournal of innate immunity2015
Multinucleated Giant Hemocytes Are Effector Cells in Cell-Mediated Immune Responses of Drosophila.
Article in Journal of innate immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Horizontal gene transfer rivals gene duplication as a source of anti-parasitoid immune innovation in the Drosophilidae.bioRxiv : the preprint server for biology · 2026Article
- Life-Stage-Specific Hematological Profiles in Yellow Mealworm Beetles (Tenebrio molitor): Reference Intervals and Hemocyte Characterization.Veterinary clinical pathology · 2026Article
- Multifaceted Defenses Against Parasitoid Wasps in Diptera.Annual review of genetics · 2025Review
- Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids.Current biology : CB · 2025Article
- Pore-Forming Toxin-Like Proteins in the Anti-Parasitoid Immune Response of Drosophila.Journal of innate immunity · 2025Article
- Cellular Immunity ofCells · 2024Article
- Germline and Somatic Cell Syncytia in Insects.Results and problems in cell differentiation · 2024Review
- Evolution of insect innate immunity through domestication of bacterial toxins.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The localization of Toll and Imd pathway and complement system components and their response to Vibrio infection in the nemertean Lineus ruber.BMC biology · 2023Article
- Distinctive features ofFrontiers in immunology · 2023Article
- Hematopoietic plasticity mapped ineLife · 2022Review
- Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids.Journal of innate immunity · 2022Article
- Differential immune responses in new and old fruit fly-parasitoid associations: Implications for their management.Frontiers in physiology · 2022Article
- Current concepts in granulomatous immune responses.Biologia futura · 2021Review
- DoesPeerJ · 2021Article
- Cellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification in the Drosophilid Zaprionus indianus.Journal of innate immunity · 2020Article
- Review
- Inter- and intra-species variation in genome-wide gene expression of Drosophila in response to parasitoid wasp attack.BMC genomics · 2017Article
- Nematocytes: Discovery and characterization of a novel anculeate hemocyte in Drosophila falleni and Drosophila phalerata.PloS one · 2017Article
- Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection.PLoS pathogens · 2016Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We identified and characterized a so far unrecognized cell type, dubbed the multinucleated giant hemocyte (MGH), in the ananassae subgroup of Drosophilidae. Here, we describe the functional and ultrastructural characteristics of this novel blood cell type as well as its characterization with a set of discriminative immunological markers. MGHs are encapsulating cells that isolate and kill the parasite without melanization. They share some properties with but differ considerably from lamellocytes, the encapsulating cells of Drosophila melanogaster, the broadly used model organism in studies of innate immunity. MGHs are nonproliferative effector cells that are derived from phagocytic cells of the sessile tissue and the circulation, but do not exhibit phagocytic activity. In contrast to lamellocytes, MGHs are gigantic cells with filamentous projections and contain many nuclei, which are the result of the fusion of several cells. Although the structure of lamellocytes and MGHs differ remarkably, their function in the elimination of parasites is similar, which is potentially the result of the convergent evolution of interactions between hosts and parasites in different geographic regions. MGHs are highly motile and share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation.
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