Evidence map›Paper›PMID 25659318›Full record

ReviewNature reviews. Microbiology2015

Post-translational protein modifications in malaria parasites.

Christian Doerig, Julian C Rayner, Artur Scherf, Andrew B Tobin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. DissectingACS omega · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Targeting SUMOylation inFrontiers in cellular and infection microbiology · 2021
    Review
  14. Article
  15. Article
  16. Development of PotentJournal of medicinal chemistry · 2020
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christian DoerigDepartment of Microbiology, Faculty of Biomedical and Psychological Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Julian C RaynerMalaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Artur Scherf1] Biology of Host-Parasite Interactions Unit, Institut Pasteur, 25 rue du Dr. Roux, Paris 75015, France. [2] CNRS URA2581, Institut Pasteur, 25 rue du Dr. Roux, Paris 75015, France.
Andrew B TobinMedical Research Council Toxicology Unit, University of Leicester, Lancaster Road, Leicester, LE1 9HN, UK.

Funding

Medical Research Council G1100712Medical Research Council MC_UP_A600_1110Wellcome Trust 098051
6 · The paper itself

Abstract

Post-translational modifications play crucial parts in regulating protein function and thereby control several fundamental aspects of eukaryotic biology, including cell signalling, protein trafficking, epigenetic control of gene expression, cell-cell interactions, and cell proliferation and differentiation. In this Review, we discuss protein modifications that have been shown to have a key role in malaria parasite biology and pathogenesis. We focus on phosphorylation, acetylation, methylation and lipidation. We provide an overview of the biological significance of these modifications and discuss prospects and progress in antimalarial drug discovery based on the inhibition of the enzymes that mediate these modifications.

Indexed as

Gene Expression RegulationProtein Processing, Post-TranslationalAdaptation, PhysiologicalEpigenesis, GeneticPlasmodiumProtozoan ProteinsProtozoan Proteins

Identifiers

PMID25659318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.