ArticlePLoS neglected tropical diseases2015
Detection of Rickettsia spp in ticks by MALDI-TOF MS.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Identification and pathogen screening of ectoparasites from companion animals in urban Vientiane, Lao PDR.PLoS neglected tropical diseases · 2025Article
- Genomic and Proteomic Analyses of Bacterial Communities ofMicroorganisms · 2025Article
- Making MALDI-TOF MS for entomological parameters accessible: A practical guide for in-house library creation.PloS one · 2025Article
- Challenges for ticks and tick-borne diseases research in Southeast Asia: Insight from the first international symposium in Cambodia.PLoS neglected tropical diseases · 2024Review
- Forensic parasitology: a new frontier in criminalistics.Forensic sciences research · 2024Review
- Bacterial Agents Detected in 418 Ticks Removed from Humans during 2014-2021, France.Emerging infectious diseases · 2023Review
- Utility of MALDI-TOF MS for determination of species identity and blood meal sources of primary malaria vectors on the Kenyan coast.Wellcome open research · 2023Article
- Applications of MALDI-TOF Mass Spectrometry to the Identification of Parasites and Arthropod Vectors of Human Diseases.Microorganisms · 2022Review
- Contemporary diagnostics for medically relevant fastidious microorganisms belonging to the genera Anaplasma,Bartonella,Coxiella,OrientiaandRickettsia.FEMS microbiology reviews · 2022Article
- Rapid LC-MS/MS detection of different carbapenemase types in carbapenemase-producing Enterobacterales.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- A single tick screening for infectious pathogens using targeted mass spectrometry.Analytical and bioanalytical chemistry · 2022Article
- Molecular and MALDI-TOF MS identification of swallow bugs Cimex hirundinis (Heteroptera: Cimicidae) and endosymbionts in France.Parasites & vectors · 2021Article
- Wolbachia detection in Aedes aegypti using MALDI-TOF MS coupled to artificial intelligence.Scientific reports · 2021Article
- Development of MALDI-TOF mass spectrometry for the identification of lice isolated from farm animals.Parasite (Paris, France) · 2020Article
- Epidemiology, Clinical Aspects, Laboratory Diagnosis and Treatment of Rickettsial Diseases in the Mediterranean Area During COVID-19 Pandemic: A Review of the Literature.Mediterranean journal of hematology and infectious diseases · 2020Review
- Rapid MALDI-TOF MS identification of commercial truffles.Scientific reports · 2019Article
- Tissue-specific signatures in tick cell line MS profiles.Parasites & vectors · 2019Article
- Identification of French Guiana sand flies using MALDI-TOF mass spectrometry with a new mass spectra library.PLoS neglected tropical diseases · 2019Article
- Identification of closely related Ixodes species by protein profiling with MALDI-TOF mass spectrometry.PloS one · 2019Article
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6 authors.
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Abstract
backgroundMatrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has been shown to be an effective tool for the rapid identification of arthropods, including tick vectors of human diseases. METHODOLOGY/PRINCIPAL
findingsThe objective of the present study was to evaluate the use of MALDI-TOF MS to identify tick species, and to determine the presence of rickettsia pathogens in the infected Ticks. Rhipicephalus sanguineus and Dermacentor marginatus Ticks infected or not by R. conorii conorii or R. slovaca, respectively, were used as experimental models. The MS profiles generated from protein extracts prepared from tick legs exhibited mass peaks that distinguished the infected and uninfected Ticks, and successfully discriminated the Rickettsia spp. A blind test was performed using Ticks that were laboratory-reared, collected in the field or removed from patients and infected or not by Rickettsia spp. A query against our in-lab arthropod MS reference database revealed that the species and infection status of all Ticks were correctly identified at the species and infection status levels. CONCLUSIONS/SIGNIFICANCE: Taken together, the present work demonstrates the utility of MALDI-TOF MS for a dual identification of tick species and intracellular bacteria. Therefore, MALDI-TOF MS is a relevant tool for the accurate detection of Rickettsia spp in Ticks for both field monitoring and entomological diagnosis. The present work offers new perspectives for the monitoring of other vector borne diseases that present public health concerns.
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