Evidence map›Paper›PMID 25659147›Full record

Trial reportPloS one2015

Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial.

Hunkyung Kim, Takao Suzuki, Miji Kim, Narumi Kojima, Noriyasu Ota, Akira Shimotoyodome, Tadashi Hase, Erika Hosoi, Hideyo Yoshida

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 86 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 21 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02918682 naunknown statusnot on this mapstarted 2019, after this paper: background citation

The Effects of a Multi-component Intervention on the Functional Capacity, Upper and Lower-body Muscle Strength, Balance and Gait in Frail Community-dwelling Older People: a Randomized Clinical Trial

TypeinterventionalSponsorUniversity of Sao PauloRan2019 to 2022Enrolled30ConditionsFrail Elderly, Exercise Therapy, Physical Therapy TechniquesArmsExercise - FIRST PHASE, Exercise - SECOND PHASE, Exercise - FOURTH PHASE, Exercise - THIRD PHASE
NCT06225271 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Effects of the Combined Intervention of Exercise, Fruit, and Vitamin Supplementation on Frailty in Older Adults: A Cohort-based Cluster- Randomized Controlled Trial

TypeinterventionalSponsorNanjing Medical UniversityRan2024 to 2026Enrolled934ConditionsFrailtyArmsthe combined intervention of exercise, fruit, and vitamin supplementation
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 21 syntheses or guidelines pooled it, 209 citations in OpenAlex.

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  13. Delaying and reversing frailty: a systematic review of primary care interventions.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019
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  18. Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hunkyung KimResearch Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Takao SuzukiNational Institute for Longevity Sciences, Aichi, Japan.
Miji KimResearch Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Narumi KojimaResearch Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Noriyasu OtaBiological Science Laboratories, Health Science, Kao Corporation, Tochigi, Japan.
Akira ShimotoyodomeBiological Science Laboratories, Health Science, Kao Corporation, Tochigi, Japan.
Tadashi HaseBiological Science Laboratories, Health Science, Kao Corporation, Tochigi, Japan.
Erika HosoiResearch Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Hideyo YoshidaResearch Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Tokyo Metropolitan Institute of Gerontology · JPKao Corporation (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the combined and separate effects of exercise and milk fat globule membrane (MFGM) supplementation on frailty, physical function, physical activity level, and hematological parameters in community-dwelling elderly Japanese women.

methodsA total of 131 frail, elderly women over 75 years were randomly assigned to one of four groups: exercise and MFGM supplementation (Ex+MFGM), exercise and placebo (Ex+Plac), MFGM supplementation, or the placebo group. The exercise group attended a 60-minute training program twice a week for three months, and the MFGM group ingested 1g of the MFGM supplement in pill form, daily for 3 months. The primary outcome measure was change in frailty status based on Fried's frailty phenotype. Secondary outcome measures included body composition, physical function and hematological parameters, and interview survey components assessing lifestyle factors. Participants were followed for 4 months post-intervention.

resultsSignificant group × time interactions were observed for usual walking speed (P = 0.005), timed up & go (P<0.001), and insulin-like growth factor-binding protein 3/insulin-like growth factor 1 ratio (P = 0.013). The frailty components revealed that weight loss, exhaustion, low physical activity, and slow walking speed were reversed, but low muscle strength did not significantly changed. Frailty reversal rate was significantly higher in the Ex+MFGM (57.6%) than in the MFGM (28.1%) or placebo (30.3%) groups at post-intervention (χ2 = 8.827, P = 0.032), and at the follow-up was also significantly greater in the Ex+MFGM (45.5%) and Ex+Plac (39.4%) groups compared with the placebo (15.2%) group (χ2 = 8.607, P = 0.035). The exercise+MFGM group had the highest odds ratio (OR) for frailty reversal at post-intervention and follow-up (OR = 3.12, 95% confidence interval (CI) = 1.13-8.60; and OR = 4.67, 95% CI = 1.45-15.08, respectively).

conclusionThis study suggests that interventions including exercise and nutrition can improve frailty status. Statistically significant additive effects of MFGM with exercise could not be confirmed in this population, and further investigation in larger samples is necessary.

trial registrationThe Japan Medical Association Clinical Trial Registry (JMACCT)JMA-IIA00069.

Indexed as

Dietary SupplementsExerciseAgedAged, 80 and overBody CompositionDouble-Blind MethodFemaleFollow-Up StudiesGlycolipidsGlycoproteinsHumansLipid DropletsTime FactorsWeight LossGlycolipidsGlycoproteinsmilk fat globule

Identifiers

PMID25659147
PMCPMC4319727
OpenAlexW1976336779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.