ArticlePloS one2015
Repetitive transcranial magnetic stimulation ameliorates anxiety-like behavior and impaired sensorimotor gating in a rat model of post-traumatic stress disorder.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03840369 (Pathophysiological Understanding and Treatment of PTSD), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pathophysiological Understanding and Treatment of PTSD: an rTMS Approach
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Neurostimulation in the treatment of psychiatric disorders: Underlying mechanisms and critical analysis of circuit-based interventions.Molecular psychiatry · 2026Review
- Repetitive Transcranial Magnetic Stimulation of the mPFC Ameliorates Stress-Induced Hyperalgesia by Alleviating Microglia Activation in Rats.Brain and behavior · 2026Article
- Time-course analysis of frontal gene expression profiles in the rat model of posttraumatic stress disorder and a comparison with the conditioned fear model.Neurobiology of stress · 2023Article
- Early- and late-phase changes of brain activity and early-phase neuromodulation in the posttraumatic stress disorder rat model.Neurobiology of stress · 2023Article
- Therapeutic non-invasive brain treatments in Alzheimer's disease: recent advances and challenges.Inflammation and regeneration · 2022Review
- Intermittent Theta Burst Stimulation Ameliorates Cognitive Deficit and Attenuates NeuroinflammationFrontiers in aging neuroscience · 2022Article
- Transcranial focused ultrasound modulates cortical and thalamic motor activity in awake sheep.Scientific reports · 2021Article
- Pulsed electromagnetic field attenuated PTSD-induced failure of conditioned fear extinction.Iranian journal of basic medical sciences · 2019Article
- Neuromodulation Strategies in Post-Traumatic Stress Disorder: From Preclinical Models to Clinical Applications.Brain sciences · 2019Review
- Electroacupuncture Pretreatment Ameliorates PTSD-Like Behaviors in Rats by Enhancing Hippocampal Neurogenesis via the Keap1/Nrf2 Antioxidant Signaling Pathway.Frontiers in cellular neuroscience · 2019Article
- Characterisation of Lamp2-deficient rats for potential new animal model of Danon disease.Scientific reports · 2018Article
- Repetitive transcranial magnetic stimulation inhibits Sirt1/MAO-A signaling in the prefrontal cortex in a rat model of depression and cortex-derived astrocytes.Molecular and cellular biochemistry · 2018Article
- rTMS Ameliorates PTSD Symptoms in Rats by Enhancing Glutamate Transmission and Synaptic Plasticity in the ACC via the PTEN/Akt Signalling Pathway.Molecular neurobiology · 2018Article
- Is prepulse modification altered by continuous theta burst stimulation? DAT1 genotype and motor threshold interact on prepulse modification following brain stimulation.European archives of psychiatry and clinical neuroscience · 2017Article
- 24-hour-restraint stress induces long-term depressive-like phenotypes in mice.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRepetitive transcranial magnetic stimulation (rTMS) has been employed for decades as a non-pharmacologic treatment for post-traumatic stress disorder (PTSD). Although a link has been suggested between PTSD and impaired sensorimotor gating (SG), studies assessing the effects of rTMS against PTSD or PTSD with impaired SG are scarce.
aimTo assess the benefit of rTMS in a rat model of PTSD.
methodsUsing a modified single prolonged stress (SPS&S) rat model of PTSD, behavioral parameters were acquired using open field test (OFT), elevated plus maze test (EPMT), and prepulse inhibition trial (PPI), with or without 7 days of high frequency (10Hz) rTMS treatment of SPS&S rats.
resultsAnxiety-like behavior, impaired SG and increased plasma level of cortisol were observed in SPS&S animals after stress for a prolonged time. Interestingly, rTMS administered immediately after stress prevented those impairment.
conclusionStress-induced anxiety-like behavior, increased plasma level of cortisol and impaired PPI occur after stress and high-frequency rTMS has the potential to ameliorate this behavior, suggesting that high frequency rTMS should be further evaluated for its use as a method for preventing PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.