Trial reportPloS one2015
Low maternal vitamin D status during the second trimester of pregnancy: a cross-sectional study in Wuxi, China.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Vitamin D levels and its influencing factors in pregnant women in mainland China: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Response to Antenatal Cholecalciferol Supplementation Is Associated With Common Vitamin D-Related Genetic Variants.The Journal of clinical endocrinology and metabolism · 2017Trial
- Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation During Pregnancy.The Journal of clinical endocrinology and metabolism · 2016Trial
- Is there a correlation between the severity of symptoms and vitamin D levels in pregnancy with hyperemesis gravidarum?Turkish journal of obstetrics and gynecology · 2025Article
- The Impact of Vitamin D Deficiency on Gestational Diabetes Mellitus Risk: A Retrospective Study.Cureus · 2024Article
- Effect of air temperature on serum 25-hydroxyvitamin D concentrations: A single institutional large-scale study in Korea.PloS one · 2024Review
- The Degree of Prepregnancy Vitamin D Deficiency Is Not Associated With Gestational Diabetes in Women Undergoing ART.Journal of the Endocrine Society · 2023Article
- Particulate matter may have a limited influence on maternal vitamin D levels.Scientific reports · 2022Article
- Serum vitamin D status among healthy children in Hainan, South China: a multi-center analysis of 10,262 children.Translational pediatrics · 2022Article
- Review
- Assessing vitamin D related genetic variants, status, and influence factors in pregnant women in Eastern and Central China.Food science & nutrition · 2020Article
- Status and influential factors of vitamin D among children aged 0 to 6 years in a Chinese population.BMC public health · 2020Article
- Prevalence of vitamin D deficiency in the pregnant women: an observational study in Shanghai, China.Archives of public health = Archives belges de sante publique · 2020Article
- High frequency of vitamin D deficiency in current pregnant Japanese women associated with UV avoidance and hypo-vitamin D diet.PloS one · 2019Article
- Review
- Thyroid Function and 25 (OH) Vitamin D Level among Sudanese Women in Early Pregnancy.Open access Macedonian journal of medical sciences · 2018Article
- [Vitamin D level at birth and influencing factors in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Weight and skin colour as predictors of vitamin D status: results of an epidemiological investigation using nationally representative data.Public health nutrition · 2017Article
- Maternal Vitamin D Status in the Late Second Trimester and the Risk of Severe Preeclampsia in Southeastern China.Nutrients · 2017Article
- Determinants of maternal vitamin D concentrations in Slovenia : A prospective observational study.Wiener klinische Wochenschrift · 2017Observational
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D deficiency is common in pregnant women, but an optimal serum vitamin D level during pregnancy has not been determined and remains an area of active research. Vitamin D data from large populations of pregnant Chinese women are still limited.
objectiveTo evaluate the vitamin D status of women in Eastern China during the second trimester of pregnancy.
methodsA hospital-based, cross-sectional, observational study. Serum 25-hydroxyvitamin D [25(OH)D] concentration was measured in samples from 5823 pregnant women in Wuxi City, China (latitude: 31.5o N), from January 2011 to June 2012.
resultsThe median serum 25(OH)D concentration was 34.0 nmol/L [2.5 nmol/L 25(OH)D = 1 ng/mL 25(OH)D]. Vitamin D deficiency [defined as 25(OH)D < 30 nmol/L according to the Institute of Medicine (National Academy of Sciences, Washington, D.C., USA)] or inadequacy [25(OH)D of 30-49.9 nmol/L] was identified in 40.7% and 38.0% of the women, respectively. Only 0.9% had a 25(OH)D level ≥ 80.0 nmol/L, which is the concentration recommended as adequate by the Endocrine Society (Washington, D.C., USA). Compared with older women, younger women were more likely to be deficient in vitamin D. There were significant differences in the 25(OH)D levels according to season. The 25(OH)D levels reached peak values in September and were correlated with (r = 0.337, P < 0.001), and fluctuated with, average monthly air temperatures.
conclusionsThere is a high prevalence of Vitamin D deficiency among pregnant Chinese women, and 25(OH)D levels varied according to season and air temperature. The results of this study also suggest that currently there is a big gap between the levels of Vitamin D detected in pregnant Chinese women and the levels recommended by the Endocrine Society.
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