ArticlePloS one2015
The expression and regulation of chemerin in the epidermis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 76 citations in OpenAlex.
- Novel antimicrobial peptides and peptide-microbiome crosstalk in Appalachian salamander skin.NPJ biofilms and microbiomes · 2025Article
- The role of chemerin, elafin, and visfatin in the pathogenesis of atopic dermatitis.Frontiers in immunology · 2025Review
- The Intersection of the Pathogenic Processes Underlying Psoriasis and the Comorbid Condition of Obesity.Life (Basel, Switzerland) · 2024Review
- The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.Cellular & molecular immunology · 2024Article
- Review
- The Chemerin Receptor CMKLR1 Requires Full-Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase-Based Binding Assay.ChemMedChem · 2022Article
- A novel chemerin receptor 1 (ChemerinFish and shellfish immunology reports · 2022Article
- Chemerin Forms: Their Generation and Activity.Biomedicines · 2022Review
- Review
- Antimicrobial Properties of a Peptide Derived from the Male Fertility Factor kl2 Protein ofCurrent issues in molecular biology · 2022Article
- Association of High Serum Chemerin with Bone Mineral Density Loss and Osteoporotic Fracture in Elderly Chinese Women.International journal of women's health · 2022Article
- Mesenchymal stromal cell-secreted CCL2 promotes antibacterial defense mechanisms through increased antimicrobial peptide expression in keratinocytes.Stem cells translational medicine · 2021Article
- Chemerin Regulates Epithelial Barrier Function of Mammary Glands in Dairy Cows.Animals : an open access journal from MDPI · 2021Article
- Expression of antimicrobial peptide genes oscillates along day/night rhythm protecting mice skin from bacteria.Experimental dermatology · 2021Article
- Molecular Mechanisms of ZC3H12C/Reg-3 Biological Activity and Its Involvement in Psoriasis Pathology.International journal of molecular sciences · 2021Article
- Redox Active Antimicrobial Peptides in Controlling Growth of Microorganisms at Body Barriers.Antioxidants (Basel, Switzerland) · 2021Review
- Chemerin-Derived Peptide ValFrontiers in microbiology · 2021Article
- Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoEJournal of oncology · 2021Article
- Adipokines in the Skin and in Dermatological Diseases.International journal of molecular sciences · 2020Review
- The methylation status of the chemerin promoter region located from - 252 to + 258 bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Chemerin is a protein ligand for the G protein-coupled receptor CMKLR1 and also binds to two atypical heptahelical receptors, CCRL2 and GPR1. Chemerin is a leukocyte attractant, adipokine, and antimicrobial protein. Although chemerin was initially identified as a highly expressed gene in healthy skin keratinocytes that was downregulated during psoriasis, the regulation of chemerin and its receptors in the skin by specific cytokines and microbial factors remains unexplored. Here we show that chemerin, CMKLR1, CCRL2 and GPR1 are expressed in human and mouse epidermis, suggesting that this tissue may be both a source and target for chemerin mediated effects. In human skin cultures, chemerin is significantly downregulated by IL-17 and IL-22, key cytokines implicated in psoriasis, whereas it is upregulated by acute phase cytokines oncostatin M and IL-1β. Moreover, we show that human keratinocytes in vitro and mouse skin in vivo respond to specific microbial signals to regulate expression levels of chemerin and its receptors. Furthermore, in a cutaneous infection model, chemerin is required for maximal bactericidal effects in vivo. Together, our findings reveal previously uncharacterized regulators of chemerin expression in skin and identify a physiologic role for chemerin in skin barrier defense against microbial pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.