ArticlePloS one2015
Angiogenin promotes U87MG cell proliferation by activating NF-κB signaling pathway and downregulating its binding partner FHL3.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- TET2-driven demethylation of ANG promotes angiogenesis and malignant transformation in oligodendroglioma.Oncogene · 2026Article
- Effects of diamond nanoparticle surface composition and the spScientific reports · 2025Article
- Molecular and clinical characterization of ANG expression in gliomas and its association with tumor-related immune response.Frontiers in medicine · 2023Article
- The Roles of FHL3 in Cancer.Frontiers in oncology · 2022Review
- Hypoxia-Induced Reactivity of Tumor-Associated Astrocytes Affects Glioma Cell Properties.Cells · 2021Article
- Late p65 nuclear translocation in glioblastoma cells indicates non-canonical TLR4 signaling and activation of DNA repair genes.Scientific reports · 2021Article
- Effects of Recombinant Angiogenin on Collagen Fiber Formation and Angiogenesis in the Dermis of Wistar Rats.Clinical, cosmetic and investigational dermatology · 2021Article
- Loss of angiogenin function is related to earlier ALS onset and a paradoxical increase in ALS duration.Scientific reports · 2020Article
- Development of an Aryloxazole Derivative as a Brain-Permeable Anti-Glioblastoma Agent.Pharmaceutics · 2019Article
- Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity.Cell reports · 2019Article
- Angiogenin Upregulation Independently Predicts Unfavorable Overall Survival in Proneural Subtype of Glioblastoma.Technology in cancer research & treatment · 2019Article
- Loss of programmed cell death 10 activates tumor cells and leads to temozolomide-resistance in glioblastoma.Journal of neuro-oncology · 2019Article
- Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.Nature communications · 2017Article
- Effects of angiogenin on granulosa and theca cell function in cattle.Animal : an international journal of animal bioscience · 2017Article
- Three decades of research on angiogenin: a review and perspective.Acta biochimica et biophysica Sinica · 2016Review
- ANG Promotes Proliferation and Invasion of the Cell of Lung Squamous Carcinoma by Directly Up-Regulating HMGA2.Journal of Cancer · 2016Article
- Mechanism and Function of Angiogenin in Apoptosis Regulation.Zhongguo sheng wu hua xue yu fen zi sheng wu xue bao = Chinese journal of biochemistry and molecular biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiogenin (Ang) is known to induce cell proliferation and inhibit apoptosis by cellular signaling pathways and its direct nuclear functions, but the mechanism of action for Ang in astrocytoma is not yet clear. Astrocytoma is the most frequent one among various neurogliomas, of which a subtype known as glioblastoma multiforme (GBM) is the most malignant brain glioma and seriously influences the life quality of the patients. The expression of Ang and Bcl-xL were detected in 28 cases of various grades of astrocytoma and 6 cases of normal human tissues by quantitative real-time PCR. The results showed that the expression of Ang and Bcl-xL positively correlated with the malignant grades. Cytological experiments indicated that Ang facilitated human glioblastoma U87MG cell proliferation and knock-down of endogenous Ang promoted cell apoptosis. Furthermore, Ang activated NF-κB pathway and entered the U87MG cell nuclei, and blocking NF-κB pathway or inhibiting Ang nuclear translocation partially suppressed Ang-induced cell proliferation. The results suggested that Ang participated in the regulation of evolution process of astrocytoma by interfering NF-κB pathway and its nucleus function. In addition, four and a half LIM domains 3 (FHL3), a novel Ang binding partner, was required for Ang-mediated HeLa cell proliferation in our previous study. We also found that knockdown of FHL3 enhanced IκBα phosphorylation and overexpression of Ang inhibited FHL3 expression in U87MG cells. Together our findings suggested that Ang could activate NF-κB pathway by regulating the expression of FHL3. In conclusion, the present study established a link between Ang and FHL3 proteins and identifies a new pathway for regulating astrocytoma progression.
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