ArticlePloS one2015
Temporal evolution of ischemic lesions in nonhuman primates: a diffusion and perfusion MRI study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Diffusion Tensor Imaging-Based Studies at the Group-Level Applied to Animal Models of Neurodegenerative Diseases.Frontiers in neuroscience · 2020Pooled it
- Contrast enhanced ultrasound and laser doppler flowmetry capture distinct aspects of tissue microvascular perfusion in nonhuman primates.Physiological reports · 2026Article
- Spreading depolarization: A wave that precedes and drives cerebral ischemic cell death-Target for neuroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Predictive Utility of Cerebral Blood Flow Transients in Experimental Stroke.Translational stroke research · 2026Article
- Progressive Evaluation of Ischemic Occlusion in a Macaque Monkey with Sudden Exacerbation of Infarction During Acute Stroke: A Case Report.Veterinary sciences · 2025Article
- Changes in cortical manifold structure following stroke and its relation to behavioral recovery in the male macaque.Nature communications · 2024Article
- Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke.Current research in neurobiology · 2023Article
- Investigation of white matter and grey matter alteration in the monkey brain following ischemic stroke by using diffusion tensor imaging.Investigative magnetic resonance imaging · 2022Article
- Magnetic resonance imaging of the monkey fetal brain in utero.Investigative magnetic resonance imaging · 2022Article
- Effects of Anesthesia on Cerebral Blood Flow and Functional Connectivity of Nonhuman Primates.Veterinary sciences · 2022Review
- A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys.Nature protocols · 2022Review
- Predicting the Severity of Neurological Impairment Caused by Ischemic Stroke Using Deep Learning Based on Diffusion-Weighted Images.Journal of clinical medicine · 2022Article
- A mobile battery-powered brain perfusion ultrasound (BPU) device designed for prehospital stroke diagnosis: correlation to perfusion MRI in healthy volunteers.Neurological research and practice · 2022Article
- Effects of alfaxalone on cerebral blood flow and intrinsic neural activity of rhesus monkeys: A comparison study with ketamine.Magnetic resonance imaging · 2021Article
- Infarct growth patterns may vary in acute stroke due to large vessel occlusion and recanalization with endovascular therapy.European radiology · 2020Article
- Large animal ischemic stroke models: replicating human stroke pathophysiology.Neural regeneration research · 2020Review
- Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion.Translational stroke research · 2020Article
- Neuroprotection by Exogenous and Endogenous Neuregulin-1 in Mouse Models of Focal Ischemic Stroke.Journal of molecular neuroscience : MN · 2019Article
- Longitudinal MRI Evaluation of Ischemic Stroke in the Basal Ganglia of a Rhesus Macaque (Comparative medicine · 2018Article
- Progressive Assessment of Ischemic Injury to White Matter Using Diffusion Tensor Imaging: A Preliminary Study of a Macaque Model of Stroke.The open neuroimaging journal · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeDiffusion-weighted imaging (DWI) and perfusion MRI were used to examine the spatiotemporal evolution of stroke lesions in adult macaques with ischemic occlusion.
methodsPermanent MCA occlusion was induced with silk sutures through an interventional approach via the femoral artery in adult rhesus monkeys (n = 8, 10-21 years old). The stroke lesions were examined with high-resolution DWI and perfusion MRI, and T2-weighted imaging (T2W) on a clinical 3T scanner at 1-6, 48, and 96 hours post occlusion and validated with H&E staining.
resultsThe stroke infarct evolved via a natural logarithmic pattern with the mean infarct growth rate = 1.38 ± 1.32 ml per logarithmic time scale (hours) (n = 7) in the hyperacute phase (1-6 hours). The mean infarct volume after 6 hours post occlusion was 3.6±2.8 ml (n = 7, by DWI) and increased to 3.9±2.9 ml (n = 5, by T2W) after 48 hours, and to 4.7±2.2ml (n = 3, by T2W) after 96 hours post occlusion. The infarct volumes predicted by the natural logarithmic function were correlated significantly with the T2W-derived lesion volumes (n = 5, r = 0.92, p = 0.01) at 48 hours post occlusion. The final infarct volumes derived from T2W were correlated significantly with those from H&E staining (r = 0.999, p < 0.0001, n = 4). In addition, the diffusion-perfusion mismatch was visible generally at 6 hours but nearly diminished at 48 hours post occlusion.
conclusionThe infarct evolution follows a natural logarithmic pattern in the hyperacute phase of stroke. The logarithmic pattern of evolution could last up to 48 hours after stroke onset and may be used to predict the infarct volume growth during the acute phase of ischemic stroke. The nonhuman primate model, MRI protocols, and post data processing strategy may provide an excellent platform for characterizing the evolution of acute stroke lesion in mechanistic studies and therapeutic interventions of stroke disease.
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