ArticlePloS one2015
Transcriptome analysis of scorpion species belonging to the Vaejovis genus.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Review
- Varying Modes of Selection Among Toxin Families in the Venoms of the Giant Desert Hairy Scorpions (Hadrurus).Journal of molecular evolution · 2023Article
- Comparative Proteomic Analysis of the Venoms from the Most Dangerous Scorpions in Morocco:Life (Basel, Switzerland) · 2023Article
- Differential venom gland gene expression analysis of juvenile and adult scorpions Androctonus crassicauda.BMC genomics · 2022Article
- Mass spectrometry-based top-down and bottom-up approaches for proteomic analysis of the Moroccan Buthus occitanus scorpion venom.FEBS open bio · 2021Article
- Article
- Effects of climate variables on the incidence of scorpion stings in Iran for five years.The journal of venomous animals and toxins including tropical diseases · 2021Article
- Scorpion Venom: Detriments and Benefits.Biomedicines · 2020Review
- Scorpion stings in pregnancy: an analysis of outcomes in 66 envenomed pregnant patients in Iran.The journal of venomous animals and toxins including tropical diseases · 2020Article
- Australian ScorpionBiomolecules · 2020Article
- Smp76, a Scorpine-Like Peptide Isolated from the Venom of the ScorpionInternational journal of peptide research and therapeutics · 2020Article
- Transcriptome annotation and characterization of novel toxins in six scorpion species.BMC genomics · 2019Article
- Transcriptomic and Proteomic Analysis of the Tentacles and Mucus ofMarine drugs · 2019Article
- Dissecting Toxicity: The Venom Gland Transcriptome and the Venom Proteome of the Highly Venomous ScorpionToxins · 2019Article
- Transcriptomic and Proteomic Analyses Reveal the Diversity of Venom Components from the Vaejovid ScorpionToxins · 2018Article
- A paratransgenic strategy to block transmission of Xylella fastidiosa from the glassy-winged sharpshooter Homalodisca vitripennis.BMC biotechnology · 2018Article
- First Transcriptome Analysis of Iranian Scorpion,Iranian journal of pharmaceutical research : IJPR · 2018Article
- A Deeper Examination of Thorellius atrox Scorpion Venom Components with Omic Techonologies.Toxins · 2017Article
- A mutant of theThe Journal of biological chemistry · 2017Article
- Recombinant expression of Intrepicalcin from the scorpion Vaejovis intrepidus and its effect on skeletal ryanodine receptors.Biochimica et biophysica acta. General subjects · 2017Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scorpions belonging to the Buthidae family have traditionally drawn much of the biochemist's attention due to the strong toxicity of their venoms. Scorpions not toxic to mammals, however, also have complex venoms. They have been shown to be an important source of bioactive peptides, some of them identified as potential drug candidates for the treatment of several emerging diseases and conditions. It is therefore important to characterize the large diversity of components found in the non-Buthidae venoms. As a contribution to this goal, this manuscript reports the construction and characterization of cDNA libraries from four scorpion species belonging to the Vaejovis genus of the Vaejovidae family: Vaejovis mexicanus, V. intrepidus, V. subcristatus and V. punctatus. Some sequences coding for channel-acting toxins were found, as expected, but the main transcribed genes in the glands actively producing venom were those coding for non disulfide-bridged peptides. The ESTs coding for putative channel-acting toxins, corresponded to sodium channel β toxins, to members of the potassium channel-acting α or κ families, and to calcium channel-acting toxins of the calcin family. Transcripts for scorpine-like peptides of two different lengths were found, with some of the species coding for the two kinds. One sequence coding for La1-like peptides, of yet unknown function, was found for each species. Finally, the most abundant transcripts corresponded to peptides belonging to the long chain multifunctional NDBP-2 family and to the short antimicrobials of the NDBP-4 family. This apparent venom composition is in correspondence with the data obtained to date for other non-Buthidae species. Our study constitutes the first approach to the characterization of the venom gland transcriptome for scorpion species belonging to the Vaejovidae family.
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