Trial reportPloS one2015
Attenuated monocyte apoptosis, a new mechanism for osteoporosis suggested by a transcriptome-wide expression study of monocytes.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- P4 medicine and osteoporosis: a systematic review.Wiener klinische Wochenschrift · 2016Pooled it
- Disease-first public-data integration with local virtual knockout prioritizes shared proteins linking osteoarthritis and osteoporosis.PloS one · 2026Article
- Investigating the impact of Wnt pathway-related genes on biomarker and diagnostic model development for osteoporosis in postmenopausal females.Scientific reports · 2024Article
- Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity.Bone research · 2024Article
- Identification of mitophagy-related biomarkers in human osteoporosis based on a machine learning model.Frontiers in physiology · 2023Article
- Immunoporosis: Role of Innate Immune Cells in Osteoporosis.Frontiers in immunology · 2021Review
- Network-based Transcriptome-wide Expression Study for Postmenopausal Osteoporosis.The Journal of clinical endocrinology and metabolism · 2020Article
- Integrative Analyses of Genes Associated With Osteoporosis in CD16+ Monocyte.Frontiers in endocrinology · 2020Article
- Integrative Analysis of Genomics and Transcriptome Data to Identify Regulation Networks in Female Osteoporosis.Frontiers in genetics · 2020Article
- Long Noncoding RNA Analyses for Osteoporosis Risk in Caucasian Women.Calcified tissue international · 2019Article
- Transcriptomic Data Identified Key Transcription Factors for Osteoporosis in Caucasian Women.Calcified tissue international · 2018Article
- Article
- Integrative computational approach to evaluate risk genes for postmenopausal osteoporosis.IET systems biology · 2018Article
- A novel approach for correction of crosstalk effects in pathway analysis and its application in osteoporosis research.Scientific reports · 2018Article
- "Omics" Signatures in Peripheral Monocytes from Women with Low BMD Condition.Journal of osteoporosis · 2018Review
- The Role of Monocyte Percentage in Osteoporosis in Male Rheumatic Diseases.American journal of men's health · 2017Article
- Network based subcellular proteomics in monocyte membrane revealed novel candidate genes involved in osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Cytosolic proteome profiling of monocytes for male osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Quantitative proteomics and integrative network analysis identified novel genes and pathways related to osteoporosis.Journal of proteomics · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundOsteoporosis is caused by excessive bone resorption (by osteoclasts) over bone formation (by osteoblasts). Monocytes are important to osteoporosis by serving as progenitors of osteoclasts and produce cytokines for osteoclastogenesis.
aimTo identify osteoporosis-related genes, we performed microarray analyses of monocytes using Affymetrix 1.0 ST arrays in 42 (including 16 pre- and 26 postmenopausal) high hip BMD (bone mineral density) vs. 31 (including 15 pre- and 16 postmenopausal) low hip BMD Caucasian female subjects. Here, high vs. low BMD is defined as belonging to top vs. bottom 30% of BMD values in population.
methodDifferential gene expression analysis in high vs. low BMD subjects was conducted in the total cohort as well as pre- and post-menopausal subjects. Focusing on the top differentially expressed genes identified in the total, the pre- and the postmenopausal subjects (with a p <5E-03), we performed replication of the findings in 3 independent datasets of microarray analyses of monocytes (total N = 125).
resultsWe identified (in the 73 subjects) and successfully replicated in all the 3 independent datasets 2 genes, DAXX and PLK3. Interestingly, both genes are apoptosis induction genes and both down-regulated in the low BMD subjects. Moreover, using the top 200 genes identified in the meta-analysis across all of the 4 microarray datasets, GO term enrichment analysis identified a number of terms related to induction of apoptosis, for which the majority of component genes are also down-regulated in the low BMD subjects. Overall, our result may suggest that there might be a decreased apoptosis activity of monocytes in the low BMD subjects.
conclusionOur study for the first time suggested a decreased apoptosis rate (hence an increased survival) of monocytes, an important osteoclastogenic cell, as a novel mechanism for osteoporosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.