Observational studyEarly human development2015
Deficient maternal zinc intake-but not folate-is associated with lower fetal heart rate variability.
Observational study in Early human development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Maternal high BMI: Sex-dimorphic alterations in maternal and offspring stress indices.Psychoneuroendocrinology · 2025Article
- Mapping Early Brain-Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Elevated Vascular Sympathetic Neurotransmission and Remodelling Is a Common Feature in a Rat Model of Foetal Programming of Hypertension and SHR.Biomedicines · 2022Article
- Association between Micronutrients and Heart Rate Variability: A Review of Human Studies.Advances in nutrition (Bethesda, Md.) · 2020Review
- Early Developmental Marginal Zinc Deficiency Affects Neurogenesis Decreasing Neuronal Number and Altering Neuronal Specification in the Adult Rat Brain.Frontiers in cellular neuroscience · 2019Article
- Cardiac changes in apoptosis, inflammation, oxidative stress, and nitric oxide system induced by prenatal and postnatal zinc deficiency in male and female rats.European journal of nutrition · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveFew studies of maternal prenatal diet and child development examine micronutrient status in relation to fetal assessment.
methodsTwenty-four-hour dietary recall of zinc and folate and 20min of fetal heart rate were collected from 3rd trimester pregnant adolescents.
resultsDeficient zinc was associated with less fetal heart rate variability. Deficient folate had no associations with HRV. Neither deficient zinc nor deficient folate was related to fetal heart rate.
conclusionsThese findings, from naturalistic observation, are consistent with emerging data on prenatal zinc supplementation using a randomized control design. PRACTICAL IMPLICATION: Taken together, the findings suggest that maternal prenatal zinc intake is an important and novel factor for understanding child ANS development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.