ArticlePLoS pathogens2015
IFNγ signaling endows DCs with the capacity to control type I inflammation during parasitic infection through promoting T-bet+ regulatory T cells.
Article in PLoS pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption.The Journal of clinical investigation · 2019Trial
- Skeletal muscle as a dynamic immunological niche for vaccination.Frontiers in immunology · 2026Review
- GATA3 regulates Th1/Th2 balance in allergic rhinitis by interacting with RUNX1.Future science OA · 2025Article
- T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses.The EMBO journal · 2025Article
- T cell-derived IFN-γ Suppresses T Follicular Helper Cell Differentiation and Antibody Responses.bioRxiv : the preprint server for biology · 2025Article
- Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TNature immunology · 2023Article
- Article
- IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.Science advances · 2022Article
- Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes.The Journal of experimental medicine · 2021Article
- MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell-Suppressive Functions.Cancer immunology research · 2021Article
- Maggot extracts promote regulatory T cell differentiation by upregulating Foxp3 in allergic rhinitis.American journal of translational research · 2021Article
- Tissue macrophages and interferon-gamma signalling control blood-stageCurrent research in immunology · 2021Article
- Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells.Cell reports · 2020Article
- Article
- Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.Cell reports · 2019Article
- Monocytes undergo multi-step differentiation in mice during oral infection byCommunications biology · 2019Article
- IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence.PloS one · 2018Article
- Gamma Interferon Mediates Experimental Cerebral Malaria by Signaling within Both the Hematopoietic and Nonhematopoietic Compartments.Infection and immunity · 2017Article
- TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN.Journal of the American Society of Nephrology : JASN · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
IFNγ signaling drives dendritic cells (DCs) to promote type I T cell (Th1) immunity. Here, we show that activation of DCs by IFNγ is equally crucial for the differentiation of a population of T-bet+ regulatory T (Treg) cells specialized to inhibit Th1 immune responses. Conditional deletion of IFNγ receptor in DCs but not in Treg cells resulted in a severe defect in this specific Treg cell subset, leading to exacerbated immune pathology during parasitic infections. Mechanistically, IFNγ-unresponsive DCs failed to produce sufficient amount of IL-27, a cytokine required for optimal T-bet induction in Treg cells. Thus, IFNγ signalling endows DCs with the ability to efficiently control a specific type of T cell immunity through promoting a corresponding Treg cell population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.