ArticlePloS one2015
Characterization of a null allelic mutant of the rice NAL1 gene reveals its role in regulating cell division.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 105 citations in OpenAlex.
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- Loci and natural alleles for leaf length and width revealed by a genome wide association study in adzuki bean.BMC plant biology · 2025Article
- QTL-seq identifies NAL1 and OsOFP19 as additive regulators of tiller number in rice (Oryza sativa L.).BMC plant biology · 2025Article
- NAL1 forms a molecular cage to regulate FZP phase separation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Advancements in Rice Leaf Development Research.Plants (Basel, Switzerland) · 2024Review
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- BrKCS6 mutation conferred a bright glossy phenotype to Chinese cabbage.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- A Structure Variation inPlants (Basel, Switzerland) · 2023Article
- NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice.BMC plant biology · 2023Article
- Serine protease NAL1 exerts pleiotropic functions through degradation of TOPLESS-related corepressor in rice.Nature plants · 2023Article
- Narrow and Stripe Leaf 2 Regulates Leaf Width by Modulating Cell Cycle Progression in Rice.Rice (New York, N.Y.) · 2023Article
- Identification of a Rice Leaf Width GeneInternational journal of molecular sciences · 2023Article
- Symbiotic compatibility between rice cultivars and arbuscular mycorrhizal fungi genotypes affects rice growth and mycorrhiza-induced resistance.Frontiers in plant science · 2023Article
- Multi-model genome-wide association studies of leaf anatomical traits and vein architecture in rice.Frontiers in plant science · 2023Article
- Partially functional NARROW LEAF1 balances leaf photosynthesis and plant architecture for greater rice yield.Plant physiology · 2022Article
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- Genetic and molecular pathways controlling rice inflorescence architecture.Frontiers in plant science · 2022Review
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leaf morphology is closely associated with cell division. In rice, mutations in Narrow leaf 1 (NAL1) show narrow leaf phenotypes. Previous studies have shown that NAL1 plays a role in regulating vein patterning and increasing grain yield in indica cultivars, but its role in leaf growth and development remains unknown. In this report, we characterized two allelic mutants of NARROW LEAF1 (NAL1), nal1-2 and nal1-3, both of which showed a 50% reduction in leaf width and length, as well as a dwarf culm. Longitudinal and transverse histological analyses of leaves and internodes revealed that cell division was suppressed in the anticlinal orientation but enhanced in the periclinal orientation in the mutants, while cell size remained unaltered. In addition to defects in cell proliferation, the mutants showed abnormal midrib in leaves. Map-based cloning revealed that nal1-2 is a null allelic mutant of NAL1 since both the whole promoter and a 404-bp fragment in the first exon of NAL1 were deleted, and that a 6-bp fragment was deleted in the mutant nal1-3. We demonstrated that NAL1 functions in the regulation of cell division as early as during leaf primordia initiation. The altered transcript level of G1- and S-phase-specific genes suggested that NAL1 affects cell cycle regulation. Heterogeneous expression of NAL1 in fission yeast (Schizosaccharomyces pombe) further supported that NAL1 affects cell division. These results suggest that NAL1 controls leaf width and plant height through its effects on cell division.
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