ArticlePloS one2015
Genetic evolution of Mycobacterium bovis causing tuberculosis in livestock and wildlife in France since 1978.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 96 citations in OpenAlex.
- Enhanced analysis of the genomic diversity ofFrontiers in microbiology · 2025Article
- Animal tuberculosis control in a disease-free country, France: does the long and winding road really lead to eradication?Irish veterinary journal · 2023Review
- Analysis of a multi-type resurgence of Mycobacterium bovis in cattle and badgers in Southwest France, 2007-2019.Veterinary research · 2023Article
- Genetic Diversity and Population Structure ofPathogens (Basel, Switzerland) · 2023Article
- Estimated Prevalence of Tuberculosis in Ruminants from Slaughterhouses in Constantine Province (Northeastern Algeria): A 10-Year Retrospective Survey (2011-2020).Life (Basel, Switzerland) · 2023Article
- Features ofMicroorganisms · 2023Article
- Unraveling the epidemiology ofFrontiers in veterinary science · 2023Article
- Geo-epidemiology of animal tuberculosis andFrontiers in microbiology · 2023Article
- Article
- A Bayesian evolutionary model towards understanding wildlife contribution to F4-family Mycobacterium bovis transmission in the South-West of France.Veterinary research · 2022Article
- Assessment of Knowledge, Attitudes, and Practices (KAP): Public Health and Economic Burden of Tuberculosis in Jarso District of West Wollega Zone, Oromia, Western Ethiopia.BioMed research international · 2022Article
- Use of Whole-Genome Sequencing to Unravel the Genetic Diversity of a PrevalentFrontiers in microbiology · 2022Article
- ISFrontiers in microbiology · 2022Article
- Article
- Inferring Mycobacterium bovis transmission between cattle and badgers using isolates from the Randomised Badger Culling Trial.PLoS pathogens · 2021Article
- Genome-wide estimation of recombination, mutation and positive selection enlightens diversification drivers of Mycobacterium bovis.Scientific reports · 2021Article
- Mycobacterium microti Infections in Free-Ranging Red Deer (Cervus elaphus).Emerging infectious diseases · 2021Review
- Whole-Genome SNP Analysis Identifies PutativeMicroorganisms · 2021Article
- Phylogenetic relationships investigation of Mycobacterium caprae strains from sympatric wild boar and goats based on whole genome sequencing.Transboundary and emerging diseases · 2021Article
- Mycobacterial Infection of Precision-Cut Lung Slices Reveals Type 1 Interferon Pathway Is Locally Induced byFrontiers in veterinary science · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the dynamics of bovine tuberculosis (bTB) in France, 4,654 M. bovis strains isolated mainly from livestock and wildlife since 1978 were characterized by spoligotyping and MLVA based on MIRU-VNTR. In our study spoligotyping allowed the discrimination of 176 types although 3 spoligotypes are predominant and account for more than half of the total strain population: SB0120 (26%), SB0134 (11%) and SB0121 (6%). In addition, 11% of the isolates, principally from Southern France, showing close spoligotypes and MIRU-VNTR types have been gathered in a family designated as the "F4-family". MLVA typing allowed extensive discrimination, particularly for strains with predominant spoligotypes, with a total of 498 genotypes, several of which were highly regionalized. The similarity of the strains' genetic relationships based on spoligotyping and MIRU-VNTR markers supports the co-existence of different clonal populations within the French M. bovis population. A genetic evolution of the strains was observed both geographically and in time. Indeed, as a result of the reduction of bTB due to the national control campaigns, a large reduction of the strains' genetic variability took place in the last ten years. However, in the regions were bTB is highly prevalent at present, cases in both livestock and in wildlife are due to the spread of unique local genotype profiles. Our results show that the highly discriminating genotyping tools used in this study for molecular studies of bTB are useful for addressing pending questions, which would lead to a better insight into the epidemiology of the disease, and for finding proper solutions for its sustainable control in France.
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