Trial reportPloS one2015
Neural circuits for cognitive appetite control in healthy and obese individuals: an fMRI study.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Cognitive reappraisal of food craving and emotions: a coordinate-based meta-analysis of fMRI studies.Social cognitive and affective neuroscience · 2024Pooled it
- A Systematic Review of Obesity and Binge Eating Associated Impairment of the Cognitive Inhibition System.Frontiers in nutrition · 2021Pooled it
- Association of Changes in Neural Targets and Dietary Outcomes among Patients with Comorbid Obesity and Depression: Post hoc Analysis of ENGAGE-2 Mechanistic Clinical Trial.The Journal of nutrition · 2023Trial
- Diminished prefrontal cortex activation in patients with binge eating disorder associates with trait impulsivity and improves after impulsivity-focused treatment based on a randomized controlled IMPULS trial.NeuroImage. Clinical · 2021Trial
- Investigating resting brain perfusion abnormalities and disease target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls.Translational psychiatry · 2020Trial
- Elevated reward response to receipt of palatable food predicts future weight variability in healthy-weight adolescents.The American journal of clinical nutrition · 2017Trial
- Functional connectivity and treatment response in obesity and eating disorders: Current evidence and empirical data.Reviews in endocrine & metabolic disorders · 2026Review
- Altered effective connectivity between the prefrontal cortex and caudate in children with overweight and obesity.International journal of obesity (2005) · 2026Article
- Investigation of region-of-interest-based functional connectivity within the default mode network among adolescents with depression complicated by obesity.BMC psychiatry · 2025Article
- Topological Reorganization and Resting-State Functional Connectivity in Functional Dyspepsia: Associations of Symptoms with Peripheral Cytokine Levels and Amygdala Nodal Centrality.Molecular neurobiology · 2025Article
- Hijacked Brain in Modern Obesity: Cue, Habit, Addiction, Emotion, and Restraint as Targets for Personalized Digital Therapy and Electroceuticals.Journal of obesity & metabolic syndrome · 2025Review
- Reward responses to vicarious feeding depend on body mass index.Cognitive, affective & behavioral neuroscience · 2025Article
- Weight Loss and Therapeutic Metabolic Effects of Tetrahydrocannabivarin (THCV)-Infused Mucoadhesive Strips.Cannabis (Albuquerque, N.M.) · 2025Article
- A latent clinical-anatomical dimension relating metabolic syndrome to brain structure and cognition.eLife · 2024Article
- Effect of Preadolescents' Obesity on Inhibitory Control During Stop-Signal Task: A Functional EEG Network Study.IEEE open journal of engineering in medicine and biology · 2024Article
- A latent clinical-anatomical dimension relating metabolic syndrome to brain structure and cognition.bioRxiv : the preprint server for biology · 2023Article
- Near-Infrared Spectroscopy: A Free-Living Neuroscience Tool to Better Understand Diabetes and Obesity.Metabolites · 2023Review
- Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures.Scientific reports · 2023Article
- Associations among body mass index, working memory performance, gray matter volume, and brain activation in healthy children.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Reward and inhibition in obesity and cigarette smoking: Neurobiological overlaps and clinical implications.Physiology & behavior · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mere sight of foods may activate the brain's reward circuitry, and humans often experience difficulties in inhibiting urges to eat upon encountering visual food signals. Imbalance between the reward circuit and those supporting inhibitory control may underlie obesity, yet brain circuits supporting volitional control of appetite and their possible dysfunction that can lead to obesity remain poorly specified. Here we delineated the brain basis of volitional appetite control in healthy and obese individuals with functional magnetic resonance imaging (fMRI). Twenty-seven morbidly obese women (mean BMI = 41.4) and fourteen age-matched normal-weight women (mean BMI = 22.6) were scanned with 1.5 Tesla fMRI while viewing food pictures. They were instructed to inhibit their urge to eat the foods, view the stimuli passively or imagine eating the foods. Across all subjects, a frontal cortical control circuit was activated during appetite inhibition versus passive viewing of the foods. Inhibition minus imagined eating (appetite control) activated bilateral precunei and parietal cortices and frontal regions spanning anterior cingulate and superior medial frontal cortices. During appetite control, obese subjects had lower responses in the medial frontal, middle cingulate and dorsal caudate nuclei. Functional connectivity of the control circuit was increased in morbidly obese versus control subjects during appetite control, which might reflect impaired integrative and executive function in obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.