Evidence map›Paper›PMID 25658367›Full record

ArticleCell stem cell2015

Can the irradiated brain be salvaged by oligodendrocyte precursor transplantation?

Marie C Harrisingh, Charles ffrench-Constant

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marie C HarrisinghMRC Centre for Regenerative Medicine, University of Edinburgh, SCRM Building, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
Charles ffrench-ConstantMRC Centre for Regenerative Medicine, University of Edinburgh, SCRM Building, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK. Electronic address: cffc@ed.ac.uk.
MRC Centre for Regenerative Medicine · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy is a mainstay of brain cancer treatment, but it causes significant complications. In this issue of Cell Stem Cell, Piao et al. (2015) derive oligodendrocyte precursors from human embryonic stem cells and show that engrafted cells replenish depleted precursor numbers, generate new myelin, and reverse behavioral defects in irradiated rats.

Indexed as

AnimalsBrainCognition DisordersFemaleHuman Embryonic Stem CellsHumansMyelin SheathOligodendroglia

Identifiers

PMID25658367
OpenAlexW2146539112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.