ArticleCell stem cell2015
Do mutational dynamics in stem cells explain the origin of common cancers?
Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Mutational signature distribution varies with DNA replication timing and strand asymmetry.Genome biology · 2018Article
- Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy.International journal of molecular sciences · 2016Review
Corrections and comments
- Comment on
Authors and funding
3 authors.
Funding
Abstract
For more than 60 years, we have known that the incidence of certain common human cancers increases with age. Recently in Science, Tomasetti and Vogelstein (2015) refined this model by providing a potential explanation, arguing that early random mutational events within individual stem cells of regenerating organs may underlie this correlation.
Indexed as
Identifiers
25658366What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.