Evidence map›Paper›PMID 25658365›Full record

ArticleCell stem cell2015

Intimacy of the niche: perivascular remodeling cuddles incoming HSCs.

Pankaj Sahai-Hernandez, David Traver

Abstract readComment
In one paragraph

Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Pankaj Sahai-HernandezDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0380, USA.
David TraverDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0380, USA. Electronic address: dtraver@ucsd.edu.

Funding

Molecular and functional dissection of zebrafish hematopoietic stem cell nicheR01DK074482 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TRAVER, DAVID · 2006 to 2024
$6.5M
VASCULAR BIOLOGY, THROMBOSIS, AND HEMOSTASIST32HL007695 · NHLBI · SCRIPPS RESEARCH INSTITUTE · PI QUIGLEY, JAMES P · 1991 to 2005
$1.9M
NHLBI NIH HHS T32 HL007695NIDDK NIH HHS R01 DK074482
6 · The paper itself

Abstract

Stem cells reside in "niches," which provide signaling cues necessary for self-renewal. In a recent issue of Cell, Tamplin et al. (2015) perform live imaging of hematopoietic stem and progenitor cells (HSPCs) and find dynamic remodeling of endothelial cells is triggered upon arrival of HSPCs at the caudal hematopoietic tissue.

Indexed as

AnimalsEndotheliumHematopoietic Stem CellsZebrafish

Identifiers

PMID25658365
PMCPMC5918686

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.