ReviewCurrent opinion in immunology2015
Sensing viral RNAs by Dicer/RIG-I like ATPases across species.
Review in Current opinion in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 68 citations in OpenAlex.
- Biochemical and structural basis of Dicer helicase function unveiled by resurrecting ancient proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Recognition of Arboviruses by the Mosquito Immune System.Biomolecules · 2023Review
- Innate Immunity Mechanisms in Marine Multicellular Organisms.Marine drugs · 2022Review
- A novel concept of human antiviral protection: It's all about RNA (Review).Biomedical reports · 2022Review
- Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators.Nature communications · 2021Article
- Untangling the roles of RNA helicases in antiviral innate immunity.PLoS pathogens · 2021Review
- Innate immunity in C. elegans.Current topics in developmental biology · 2021Review
- Sending Out Alarms: A Perspective on Intercellular Communications in Insect Antiviral Immune Response.Frontiers in immunology · 2021Review
- Different mechanisms for translocation by monomeric and hexameric helicases.Current opinion in structural biology · 2020Review
- Perception of double-stranded RNA in plant antiviral immunity.Molecular plant pathology · 2019Review
- The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans.Viruses · 2019Review
- A Transgenic Flock House Virus Replicon Reveals an RNAi Independent Antiviral Mechanism Acting inG3 (Bethesda, Md.) · 2019Article
- The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.Immunity · 2018Article
- Neurodegenerative diseases have genetic hallmarks of autoinflammatory disease.Human molecular genetics · 2018Review
- Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects.Cell host & microbe · 2018Article
- The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells.The EMBO journal · 2018Article
- Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signalling Framework in Invertebrates.Scientific reports · 2017Article
- Innate and intrinsic antiviral immunity in Drosophila.Cellular and molecular life sciences : CMLS · 2017Review
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Induction of antiviral immunity in vertebrates and invertebrates relies on members of the RIG-I-like receptor and Dicer families, respectively. Although these proteins have different size and domain composition, members of both families share a conserved DECH-box helicase domain. This helicase, also known as a duplex RNA activated ATPase, or DRA domain, plays an important role in viral RNA sensing. Crystallographic and electron microscopy studies of the RIG-I and Dicer DRA domains indicate a common structure and that similar conformational changes are induced by dsRNA binding. Genetic and biochemical studies on the function and regulation of DRAs reveal similarities, but also some differences, between viral RNA sensing mechanisms in nematodes, flies and mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.