Evidence map›Paper›PMID 25658202›Full record

ArticleMolecular cell2015

Chaos controlled: discovery of a powerful amyloid inhibitor.

Roger D Klein, Scott J Hultgren

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Roger D KleinDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Scott J HultgrenDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: hultgren@wusm.wustl.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Molecular Cell, Evans et al. (2015) report that the hitherto largely unstudied CsgC protein is responsible for the suppression of premature amyloidogenesis within the cellular periplasm, preventing early aggregation and cellular toxicity.

Indexed as

alpha-SynucleinEscherichia coliEscherichia coli ProteinsHumansProtein Aggregatesalpha-SynucleincsgA protein, E coliCsgC protein, E coliEscherichia coli ProteinsProtein Aggregates

Identifiers

PMID25658202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.