ArticleMolecules (Basel, Switzerland)2015
Synthesis and evaluation of new 1,5-diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole derivatives as potential antidepressant agents.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Pyrazole and Pyrazoline-Based EGFR TK Inhibitors: A Review Study Emphasizing Structure-Activity Relationship (SAR).Medicinal chemistry (Shariqah (United Arab Emirates)) · 2026Review
- Review of the recent advances of pyrazole derivatives as selective COX-2 inhibitors for treating inflammation.Molecular diversity · 2025Review
- Design, Synthesis, and Evaluation of New Pyrazolines As Small Molecule Inhibitors of Acetylcholinesterase.ACS omega · 2024Article
- Synthesis of anti-depressant moleculesRSC advances · 2024Review
- Design, Synthesis, and Evaluation of a New Series of 2-Pyrazolines as Potential Antileukemic Agents.ACS omega · 2023Article
- Exploration of Thiourea-Based Scaffolds for the Construction of Bacterial Ureases Inhibitors.ACS omega · 2023Article
- Multicomponent Reactions Using C,N-Binucleophilic Nature of Aminopyrazoles: Construction of Pyrazole-Fused Heterocycles.Topics in current chemistry (Cham) · 2023Review
- Novel Thiopyrano[2,3-ACS omega · 2023Article
- New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations.Journal of enzyme inhibition and medicinal chemistry · 2022Article
- Synthesis, Anticancer and Antitubercular Properties of New Chalcones and Their Nitrogen-Containing Five-Membered Heterocyclic Hybrids Bearing Sulfonamide Moiety.International journal of molecular sciences · 2022Article
- Construction of Spirooxindole Analogues Engrafted with Indole and Pyrazole Scaffolds as Acetylcholinesterase Inhibitors.ACS omega · 2021Article
- Substituted Pyrazoles and Their Heteroannulated Analogs-Recent Syntheses and Biological Activities.Molecules (Basel, Switzerland) · 2021Review
- Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress.Molecules (Basel, Switzerland) · 2018Article
- Microwave-assisted green synthesis of 4,5-dihydro-1H-pyrazole-1-carbothioamides in water.Molecular diversity · 2018Article
- 5-Aminopyrazole as precursor in design and synthesis of fused pyrazoloazines.Beilstein journal of organic chemistry · 2018Review
- Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents.Molecules (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a-s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test (MFST). The effects of the compounds on spontaneous locomotor activity were also investigated using an activity cage apparatus. Among these derivatives, compounds 2b, 2d, 2f, 2o, and 2r decreased both horizontal and vertical activity number of the mice. On the other hand, compounds 2a, 2h, 2j, 2k, 2l, 2m, and 2n, which did not induce any significant change in the locomotor activity, significantly shortened the immobility time of mice in TST and MFST, representing the presence of the antidepressant-like effect. Additionally, the same compounds increased the swimming time of mice in MFST without any change in climbing duration, similar to the reference drug fluoxetine (10 mg/kg). In the light of previous papers examining the effects of pyrazolines on central nervous system, this study, once more, pointed out remarkable antidepressant activity potential of pyrazoline derivatives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.