ArticlePloS one2015
Comparative genomic analysis of 45 type strains of the genus Bifidobacterium: a snapshot of its genetic diversity and evolution.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 104 citations in OpenAlex.
- Bifidobacteria: biogeography, host adaptation and ecological functions.Nature reviews. Microbiology · 2026Review
- Exploring Bifidobacteria-Fermented Dairy Products: Innovations, Challenges, and Health-Related Insights.Current microbiology · 2026Review
- Draft genome sequence ofMicrobiology resource announcements · 2025Article
- Comparative Genomics and Adaptive Evolution ofFoods (Basel, Switzerland) · 2025Article
- Assessment of gut microbiota in the elderly with sarcopenic obesity: a case-control study.Journal of diabetes and metabolic disorders · 2025Article
- Review
- Probiotics: insights and new opportunities forCritical reviews in microbiology · 2023Review
- Identification of conserved genomic signatures specific to3 Biotech · 2023Article
- Assessing the Safety and Probiotic Characteristics ofMicroorganisms · 2023Article
- Stress Response in Bifidobacteria.Microbiology and molecular biology reviews : MMBR · 2022Review
- Pan-genome evolution and its association with divergence of metabolic functions in Bifidobacterium genus.World journal of microbiology & biotechnology · 2022Article
- Phylogenies of the 16S rRNA gene and its hypervariable regions lack concordance with core genome phylogenies.Microbiome · 2022Article
- Comparative genomic analysis revealed genetic divergence between Bifidobacterium catenulatum subspecies present in infant versus adult guts.BMC microbiology · 2022Article
- Genome-Wide Assessment of Stress-Associated Genes in Bifidobacteria.Applied and environmental microbiology · 2022Article
- Colonized Niche, Evolution and Function Signatures ofFoods (Basel, Switzerland) · 2021Article
- Comparative Genomic Analysis of NovelMicroorganisms · 2021Article
- The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host's Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19.International journal of molecular sciences · 2021Review
- Targeted High-Resolution Taxonomic Identification ofNutrients · 2021Article
- Host-Diet Effect on the Metabolism ofGenes · 2021Article
- The Tetracycline Resistance Gene,Frontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bifidobacteria are well known for their human health-promoting effects and are therefore widely applied in the food industry. Members of the Bifidobacterium genus were first identified from the human gastrointestinal tract and were then found to be widely distributed across various ecological niches. Although the genetic diversity of Bifidobacterium has been determined based on several marker genes or a few genomes, the global diversity and evolution scenario for the entire genus remain unresolved. The present study comparatively analyzed the genomes of 45 type strains. We built a robust genealogy for Bifidobacterium based on 402 core genes and defined its root according to the phylogeny of the tree of bacteria. Our results support that all human isolates are of younger lineages, and although species isolated from bees dominate the more ancient lineages, the bee was not necessarily the original host for bifidobacteria. Moreover, the species isolated from different hosts are enriched with specific gene sets, suggesting host-specific adaptation. Notably, bee-specific genes are strongly associated with respiratory metabolism and are potential in helping those bacteria adapt to the oxygen-rich gut environment in bees. This study provides a snapshot of the genetic diversity and evolution of Bifidobacterium, paving the way for future studies on the taxonomy and functional genomics of the genus.
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