Evidence map›Paper›PMID 25657894›Full record

ReviewCurrent oral health reports

The Link Between Periodontitis and Rheumatoid Arthritis: A Periodontist's Perspective.

Jeffrey B Payne, Lorne M Golub, Geoffrey M Thiele, Ted R Mikuls

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current oral health reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02379975 (Evaluation of Non-surgical Periodontal Therapy in Patients With Rheumatoid Arthritis), which is not on this map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02379975 nacompletednot on this map

Evaluation of Non-surgical Periodontal Therapy in Patients With Rheumatoid Arthritis

TypeinterventionalSponsorCAIO VINICIUS GONÇALVES ROMAN TORRESRan2013 to 2014Enrolled56ConditionsRheumatoid Arthritis, PeriodontitisArmsNon-surgical Periodontal Therapy
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 93 citations in OpenAlex.

  1. Trial
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  4. Exploring oral health care needs of Canadians with rheumatic diseases: a qualitative study.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2026
    Article
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  11. Contribution of -Omics Technologies in the Study ofInternational journal of molecular sciences · 2022
    Review
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  19. Article
  20. The Photomodulation Activity of Metformin Against Oral Microbiome.Journal of lasers in medical sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jeffrey B PayneDepartment of Surgical Specialties, Division of Periodontics, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE USA ; Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE USA ; Department of Surgical Specialties, College of Dentistry, University of Nebraska Medical Center, 40th & Holdrege, Lincoln, NE 68583 USA.
Lorne M GolubDepartment of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, New York 11794-8700 USA.
Geoffrey M ThieleOmaha Veterans Affairs Medical Center (VAMC) and Nebraska Arthritis Outcomes Research Center, Division of Rheumatology, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, 983025 Nebraska Medical Center, Omaha, NE 68198-3025 USA.
Ted R MikulsOmaha Veterans Affairs Medical Center (VAMC) and Nebraska Arthritis Outcomes Research Center, Division of Rheumatology, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, 983025 Nebraska Medical Center, Omaha, NE 68198-3025 USA.
University of Nebraska Medical Center · USStony Brook School · US

Funding

Environmental Factors and Autoantibody Expression in Rheumatoid ArthritisI01CX000896 · VA · OMAHA VA MEDICAL CENTER · PI MIKULS, TED RICHARD · 2014 to 2017
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CSRD VA I01 CX000896
6 · The paper itself

Abstract

In this review, we critically evaluate the case-control studies examining the relationship between rheumatoid arthritis (RA) and periodontitis, two common chronic inflammatory diseases with a similar host-mediated pathogenesis. We review the "two-hit" periodontitis model that our group previously proposed, in which we elucidate how a systemic disease such as RA can potentially exacerbate or initiate periodontitis. Furthermore, we discuss adjunctive host modulation therapy, originally developed for periodontitis (i.e., subantimicrobial-dose doxycycline alone or in combination with an anti-inflammatory agent), to simultaneously mitigate RA and periodontitis. Finally, we review studies describing periodontal treatment effects on both RA disease activity measures and systemic inflammation. Current evidence suggests that an association exists between periodontitis and RA. Well-designed multicenter longitudinal clinical trials and studies with sufficient sample sizes are needed to ascertain the temporal relationship between these two diseases and whether periodontal treatment can reduce the severity of RA or prevent its onset.

Indexed as

Alveolar bone lossCase–control studiesPeriodontitisRheumatoid arthritisSubantimicrobial dose doxycycline

Identifiers

PMID25657894
PMCPMC4312393
OpenAlexW1976734051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.