ArticleBiomedical optics express2015
Visualization of fluid drainage pathways in lymphatic vessels and lymph nodes using a mouse model to test a lymphatic drug delivery system.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Lymphatic topology reveals a novel intranodal lympho-venous shunt.The Journal of pathology · 2026Article
- Drug Combination Nanoparticles Containing Gemcitabine and Paclitaxel Enable Orthotopic 4T1 Breast Tumor Regression.Cancers · 2024Article
- Advancing insights into in vivo meningeal lymphatic vessels with stereoscopic wide-field photoacoustic microscopy.Light, science & applications · 2024Article
- Drug formulation augments the therapeutic response of carboplatin administered through a lymphatic drug delivery system.Cancer science · 2023Article
- Intranodal delivery of modified docetaxel: Innovative therapeutic method to inhibit tumor cell growth in lymph nodes.Cancer science · 2022Article
- Dermal Lymphatic Capillaries Do Not Obey Murray's Law.Frontiers in cardiovascular medicine · 2022Article
- The Therapeutic Effect of Second Near-Infrared Absorbing Gold Nanorods on Metastatic Lymph Nodes via Lymphatic Delivery System.Pharmaceutics · 2021Article
- A model system for studying superselective radiotherapy of lymph node metastasis in mice with swollen lymph nodes.Clinical and translational radiation oncology · 2020Article
- Noninvasive and real-time pharmacokinetics imaging of polymeric nanoagents in the thoracoepigastric vein networks of living mice.Journal of biomedical optics · 2019Article
- Development of a mouse model for the visual and quantitative assessment of lymphatic trafficking and function by in vivo imaging.Scientific reports · 2018Article
- AnJournal of the Royal Society, Interface · 2018Article
- Therapeutic effect of cisplatin given with a lymphatic drug delivery system on false-negative metastatic lymph nodes.Cancer science · 2017Article
- Evaluation of the enhanced permeability and retention effect in the early stages of lymph node metastasis.Cancer science · 2017Article
- A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy.Scientific reports · 2017Article
- New concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network.Scientific reports · 2016Article
- Characterization of internodal collecting lymphatic vessel function after surgical removal of an axillary lymph node in mice.Biomedical optics express · 2016Article
- Early diagnosis of lymph node metastasis: Importance of intranodal pressures.Cancer science · 2016Article
- A Novel Treatment Method for Lymph Node Metastasis Using a Lymphatic Drug Delivery System with Nano/Microbubbles and Ultrasound.Journal of Cancer · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curing/preventing micrometastasis to lymph nodes (LNs) located outside the surgically resected area is essential for improving the morbidity and mortality associated with breast cancer and head and neck cancer. However, no lymphatic therapy system exists that can deliver drugs to LNs located outside the dissection area. Here, we demonstrate proof of concept for a drug delivery system using MXH10/Mo-lpr/lpr mice that exhibit systemic lymphadenopathy, with some peripheral LNs being as large as 10 mm in diameter. We report that a fluorescent solution injected into the subiliac LN (defined as the upstream LN within the dissection area) was delivered successfully to the proper axillary LN (defined as the downstream LN outside the dissection area) through the lymphatic vessels. Our results suggest that this approach could be used before surgical resection to deliver drugs to downstream LNs outside the dissection area. We anticipate that our methodology could be applied clinically, before surgical resection, to cure/prevent micrometastasis in LNs outside the dissection area, using techniques such as ultrasound-guided internal jugular vein catheterization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.