Evidence map›Paper›PMID 25657872›Full record

ArticleBiomedical optics express2015

Femtosecond laser bone ablation with a high repetition rate fiber laser source.

Luke J Mortensen, Clemens Alt, Raphaël Turcotte, Marissa Masek, Tzu-Ming Liu, Daniel C Côté, Chris Xu, Giuseppe Intini, Charles P Lin

Abstract read
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Two-Photon Endomicroscopy for Image-Guided Magnetic Micro-Agents.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
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  7. Laser Micromachining of Bone as a Tool for Studying Bone Marrow Biology.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  8. Article
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  15. Article
  16. Fast axial scanning for 2-photon microscopy using liquid lens technology.Proceedings of SPIE--the International Society for Optical Engineering · 2017
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luke J MortensenDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA ; Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Clemens AltAdvanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Raphaël TurcotteAdvanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA ; Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.
Marissa MasekAdvanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Tzu-Ming LiuAdvanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA ; Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
Daniel C CôtéCentre de Recherche Université Laval Robert-Giffard, Université Laval, Québec, QC G1J2G3, Canada.
Chris XuSchool of Applied and Engineering Physics, Cornell University, Ithaca, New York, USA.
Giuseppe IntiniDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA ; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA ; Giuseppe_Intini@hsdm.harvard.edu ; Co-corresponding authors.
Charles P LinAdvanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA ; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA ; Co-corresponding authors.

Funding

Multi-wavelength femtosecond laser sources for intravital multiphoton microscopyR01EB017274 · NIBIB · CORNELL UNIVERSITY · PI LIN, CHARLES P., XU, CHRIS · 2013 to 2016
$2.6M
BMP2 regulation of the intramembranous bone stem cell nicheR00DE021069 · NIDCR · HARVARD MEDICAL SCHOOL · PI INTINI, GIUSEPPE · 2012 to 2014
$738k
BMP2 regulation of the intramembranous bone stem cell nicheK99DE021069 · NIDCR · HARVARD MEDICAL SCHOOL · PI INTINI, GIUSEPPE · 2010 to 2011
$260k
NIBIB NIH HHS R01 EB017274NIDCR NIH HHS K99 DE021069NIDCR NIH HHS R00 DE021069
6 · The paper itself

Abstract

Femtosecond laser pulses can be used to perform very precise cutting of material, including biological samples from subcellular organelles to large areas of bone, through plasma-mediated ablation. The use of a kilohertz regenerative amplifier is usually needed to obtain the pulse energy required for ablation. This work investigates a 5 megahertz compact fiber laser for near-video rate imaging and ablation in bone. After optimization of ablation efficiency and reduction in autofluorescence, the system is demonstrated for the in vivo study of bone regeneration. Image-guided creation of a bone defect and longitudinal evaluation of cellular injury response in the defect provides insight into the bone regeneration process.

Indexed as

(060.4370) Nonlinear optics, fibers(170.1020) Ablation of tissue(170.2520) Fluorescence microscopy(180.4315) Nonlinear microscopy

Identifiers

PMID25657872
PMCPMC4317121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.