Evidence map›Paper›PMID 25657871›Full record

ArticleBiomedical optics express2015

Deep brain light stimulation effects on glutamate and dopamine concentration.

Jinn-Rung Kuo, Shih-Shian Lin, Janelle Liu, Shih-How Chen, Chung-Chin Chio, Jhi-Joung Wang, Jia-Ming Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. The Evolution of Neuroprosthetic Interfaces.Critical reviews in biomedical engineering · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jinn-Rung KuoDepartments of Neurosurgery, Chi-Mei Medical Center, Tainan, Taiwan ; Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan.
Shih-Shian LinNeurophotonics Laboratory, College of Photonics, National Chiao Tung University, Tainan, Taiwan.
Janelle LiuNeuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA.
Shih-How ChenNeurophotonics Laboratory, College of Photonics, National Chiao Tung University, Tainan, Taiwan.
Chung-Chin ChioDepartments of Neurosurgery, Chi-Mei Medical Center, Tainan, Taiwan.
Jhi-Joung WangMedical Research, Chi-Mei Medical Center, Tainan, Taiwan.
Jia-Ming LiuNeurophotonics Laboratory, College of Photonics, National Chiao Tung University, Tainan, Taiwan ; Department of Electrical Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Chi Mei Medical Center · TWNational Yang Ming Chiao Tung University · TWUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compared to deep brain electrical stimulation, which has been applied to treating pathological brain diseases, little work has been done on the effect of deep brain light stimulation. A fiber-coupled laser stimulator at 840 nm wavelength and 130 Hz pulse repetition rate is developed in this work for deep brain light stimulation in a rat model. Concentration changes in glutamate and dopamine in the striatum are observed using a microdialysis probe when the subthalamic nucleus (STN) is stimulated at various optical power levels. Experimental results show that light stimulation causes the concentration of glutamate to decrease while that of dopamine is increased. This suggests that deep brain light stimulation of the STN is a promising therapeutic strategy for dopamine-related diseases such as Parkinson's disease. The stimulator developed for this work is useful for deep brain light stimulation in biomedical research.

Indexed as

(170.0170) Medical optics and biotechnology(170.1420) Biology(170.1610) Clinical applications(170.3660) Light propagation in tissues(170.3890) Medical optics instrumentation(170.5180) Photodynamic therapy

Identifiers

PMID25657871
PMCPMC4317125
OpenAlexW2049364239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.