Evidence map›Paper›PMID 25657870›Full record

ArticleBiomedical optics express2015

Non-contact acoustic radiation force impulse microscopy via photoacoustic detection for probing breast cancer cell mechanics.

Jae Youn Hwang, Bong Jin Kang, Changyang Lee, Hyung Ham Kim, Jinhyoung Park, Qifa Zhou, K Kirk Shung

Abstract read
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Sono-Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. A Novel Fisheye-Lens-Based Photoacoustic System.Sensors (Basel, Switzerland) · 2016
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jae Youn HwangDepartment of Information and Communication Engineering, Daegu Gyeongbuk Institute of Science & Technology, Daegu, South Korea.
Bong Jin KangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Changyang LeeDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Hyung Ham KimDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Jinhyoung ParkDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA ; qifazhou@usc.edu.
Qifa ZhouDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA ; Co-corresponding authors ; qifazhou@usc.edu.
K Kirk ShungDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.

Funding

A Resource on Medical Ultrasonic Transducer TechnologyP41EB002182 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHUNG, K KIRK · 2003 to 2016
$13.3M
Acoustic Trapping of Small Biological ParticlesR01EB012058 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHUNG, K KIRK · 2010 to 2013
$2.3M
NIBIB NIH HHS P41 EB002182NIBIB NIH HHS R01 EB012058
6 · The paper itself

Abstract

We demonstrate a novel non-contact method: acoustic radiation force impulse microscopy via photoacoustic detection (PA-ARFI), capable of probing cell mechanics. A 30 MHz lithium niobate ultrasound transducer is utilized for both detection of phatoacoustic signals and generation of acoustic radiation force. To track cell membrane displacements by acoustic radiation force, functionalized single-walled carbon nanotubes are attached to cell membrane. Using the developed microscopy evaluated with agar phantoms, the mechanics of highly- and weakly-metastatic breast cancer cells are quantified. These results clearly show that the PA-ARFI microscopy may serve as a novel tool to probe mechanics of single breast cancer cells.

Indexed as

(170.0180) Microscopy(170.5120) Photoacoustic imaging(170.7170) Ultrasound

Identifiers

PMID25657870
PMCPMC4317122

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.