ArticleJournal of neurodevelopmental disorders2015
Patterns of autism spectrum symptomatology in individuals with Down syndrome without comorbid autism spectrum disorder.
Article in Journal of neurodevelopmental disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Alexithymia in neurodevelopmental populations: a scoping review of Down syndrome, autism spectrum disorder, and dual diagnosis.Frontiers in psychology · 2026Pooled it
- Autism and Down syndrome: early identification and diagnosis.Arquivos de neuro-psiquiatria · 2022Pooled it
- Short-term and Long-term Stability of the Autism Diagnostic Observation Schedule (ADOS-2) Calibrated Comparison Scores (CCS) and Classification Scores in Youth with Down Syndrome or Fragile X Syndrome with Intellectual Disability.Journal of autism and developmental disorders · 2026Article
- Caregiver-reported social foundations and cognitive regulation in toddlers with Down syndrome.Frontiers in psychiatry · 2026Article
- Characterizing Autism Traits in Toddlers with Down Syndrome: Preliminary Associations with Language, Executive Functioning, and Other Developmental Domains.Behavioral sciences (Basel, Switzerland) · 2025Article
- Alternative Diagnoses in the Work Up of Down Syndrome Regression Disorder.Journal of autism and developmental disorders · 2025Article
- Trisomy 21 and Congenital Heart Disease: Impact on Health and Functional Outcomes From Birth Through Adolescence: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2024Review
- A clinical-translational review of sleep problems in neurodevelopmental disabilities.Journal of neurodevelopmental disorders · 2024Review
- Autism Spectrum Disorder in Down Syndrome: Experiences from Caregivers.Journal of autism and developmental disorders · 2024Article
- Pragmatic competence in people with dual diagnosis: down syndrome and autism spectrum disorder.BMC psychology · 2024Article
- Bridging the Communication Gap Between People With Cognitive Impairments and Their Caregivers Using mHealth Apps: User-Centered Design and Evaluation Study With People With 22q11 Deletion Syndrome.JMIR human factors · 2023Article
- Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly.Frontiers in molecular neuroscience · 2023Review
- Using the Social Skills Improvement System (SSiS) Rating Scales to assess social skills in youth with Down syndrome.Frontiers in psychology · 2023Article
- Health-related quality of life and family functioning of primary caregivers of children with down syndrome.Frontiers in psychiatry · 2023Article
- Patterns and predictors of adaptive skills in 2- to 7-year-old children with Down syndrome.Journal of neurodevelopmental disorders · 2022Article
- Latent profiles of autism symptoms in children and adolescents with Down syndrome.Journal of intellectual disability research : JIDR · 2022Article
- Parenting Stress in Mothers of Children and Adolescents with Down Syndrome.Journal of clinical medicine · 2022Article
- Considerations for measuring individual outcomes across contexts in Down syndrome: Implications for research and clinical trials.International review of research in developmental disabilities · 2022Article
- Age and gender-related differences in quality of life of Bangladeshi patients with Down Syndrome: A cross-sectional study.Heliyon · 2022Article
- Symptoms of Autism, Comorbid Mental Health Conditions and Challenging Behaviors among Toddlers with Down Syndrome at Low Risk for ASD-Characterization Using the BISCUIT-Parts 1-3.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPrevalence estimates of autism spectrum disorder (ASD) in Down syndrome (DS) are highly varied. This variation is partly due to the difficulty of screening for and diagnosing comorbid ASD in individuals with a syndrome that carries its own set of social communicative and behavioral difficulties that are not well documented. The aim of this study was to identify the typical range of social communicative impairments observed in children, adolescents, and young adults with DS who do not have comorbid ASD.
methodsWe examined patterns of scores from the five subscales of the Social Responsiveness Scale (SRS) in 46 individuals with DS (ages 10-21 years) without comorbid ASD relative to the published normative sample. We also explored the correlations between SRS symptomatology and age, nonverbal cognition, and receptive language.
resultsSRS scores were elevated (i.e., more ASD symptoms endorsed), with mean scores falling into the clinically significant range. Analysis by subscale revealed a specific pattern, with Autistic Mannerisms and Social Cognition scores significantly more elevated than Social Communication scores, which were significantly more elevated than Social Awareness and Social Motivation scores. Correlations between SRS scores and the other measures varied by subscale.
conclusionsGeneral elevated ASD symptomatology on the SRS indicates the need for developing population-based norms specific to DS. The pattern of scores across subscales should inform clinicians of the typical range of behaviors observed in DS so that individuals with atypical patterns of behavior can be more easily identified and considered for a full ASD evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.