ArticleResearch in pharmaceutical sciences
The effects of aqueous extract of Boswellia Serrata on hippocampal region CA1 and learning deficit in kindled rats.
Article in Research in pharmaceutical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
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- Subchronic Exposure to Mixture of Cadmium, Copper, and Nickel Induces Neurobehavioral Deficits and Hippocampal Oxidative Stress of Wistar Rats.Biological trace element research · 2025Article
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- Melatonin Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat.Biological trace element research · 2021Article
- Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats.Environmental analysis, health and toxicology · 2020Article
- GenusIranian journal of basic medical sciences · 2020Review
- Effect of acute pentylenetetrazol injection induced epileptic seizures on rat dentate gyrus at different postnatal ages.Anatomy & cell biology · 2020Article
- Protective effect of crocin on electromagnetic field-induced testicular damage and heat shock protein A2 expression in male BALB/c mice.Iranian journal of basic medical sciences · 2020Article
- Acute and chronic effects of morphine on Low-MgResearch in pharmaceutical sciences · 2019Article
- Anticonvulsant Effects of the Hydroalcoholic Extract ofJournal of epilepsy research · 2017Article
- Curcumin improves liver damage in male mice exposed to nicotine.Journal of traditional and complementary medicine · 2016Article
- The effect of time and temperature on viability and performance of Langerhans islets separated from Balb/c mouse after death.Advanced biomedical research · 2015Article
- Protective Role of Crocin Against Nicotine-induced Damages on Male Mice Liver.International journal of preventive medicine · 2015Article
- Improvement ofInternational journal of applied & basic medical researchArticle
- Ameliorative effects of crocin against electromagnetic field-induced oxidative stress and liver and kidney injuries in mice.Avicenna journal of phytomedicineArticle
- The effects of kindling during pregnancy on long-term potentiation (LTP) induction and MResearch in pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temporal lobe epilepsy (TLE) is a disorder of the central nervous system in which hippocampus is mostly involved and causes memory impairment. Kindling is a model of inducing epilepsy which is created through pentylenetetrazol (PTZ) administration. This study examines the role of the aqueous extract of Boswellia on the learning and development of brain (formation of dendritic branches and axons) of the PTZ-induced kindled rats. The study is conducted on sixty-four male rats divided into 8 groups. Kindling seizures are induced by three injections of 25 mg/kg of PTZ every 15 min. The aqueous extracts (0, 0.1, 0.5, 1 g/kg, i.p) are administrated to all animals for three consecutive days. Passive avoidance learning of animals is examined using shuttle box apparatus and step-through latency (STL) method. Rats are anesthetized and their brains are fixed by transcardial perfusion method and are analyzed by morphometric methods after applying Golgi and Cresyl violet staining methods. PTZ-induced kindling indicates a significant decrease in the number of pyramidal neurons and dendritic spines in hippocampal region cornu ammonis (CA1). The STL of the kindled rats is significantly reduced compared with control ones. Also, Boswellia extract dramatically increased the number of neuronal processes in CA1 region and improves passive-avoidance learning ability in both control and PTZ-kindled animals in 1 g/kg dose administration of Boswellia extract, especially at high doses can eliminate adverse effects of seizures on cognitive function in hippocampal area CA1 in rats.
Indexed as
Identifiers
25657807PMC4318003W1547629071What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.