ArticleNeural regeneration research2012
Gene expression profiling of the rat sciatic nerve in early Wallerian degeneration after injury.
Article in Neural regeneration research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 20 citations in OpenAlex.
- Manipulation of Wnt Signaling Pathway during Peripheral Nerve Regeneration.Cellular and molecular neurobiology · 2026Article
- Investigating How Thbs4 Regulates Degeneration and Regeneration of the Peripheral Nerve.Biomedicines · 2025Article
- The dual roles of chemokines in peripheral nerve injury and repair.Inflammation and regeneration · 2025Review
- TGF-β1 Improves Nerve Regeneration and Functional Recovery After Sciatic Nerve Injury by Alleviating Inflammation.Biomedicines · 2025Article
- Fas ligand regulate nerve injury and repair by affecting AKT, β-catenin, and NF-κB pathways.IBRO neuroscience reports · 2024Article
- Identifying candidate genes associated with hippocampal dysfunction in a hemiparkinsonian rat model by transcriptomic profiling.Animal cells and systems · 2024Article
- Integrative Analysis Reveals the Expression Pattern of SOX9 in Satellite Glial Cells after Sciatic Nerve Injury.Brain sciences · 2023Article
- Baculoviral inhibitor of apoptosis protein repeat-containing protein 3 delays early Wallerian degeneration after sciatic nerve injury.Neural regeneration research · 2022Article
- Erectile dysfunction resulting from pelvic surgery is associated with changes in cavernosal gene expression indicative of cavernous nerve injury.Andrologia · 2022Article
- Interactions Among Nerve Regeneration, Angiogenesis, and the Immune Response Immediately After Sciatic Nerve Crush Injury in Sprague-Dawley Rats.Frontiers in cellular neuroscience · 2021Article
- Article
- Genetic changes in rat proximal nerve stumps after sciatic nerve transection.Annals of translational medicine · 2019Article
- Analysis of transcriptome sequencing of sciatic nerves in Sprague-Dawley rats of different ages.Neural regeneration research · 2018Article
- Heparanase attenuates axon degeneration following sciatic nerve transection.Scientific reports · 2018Article
- Fas Ligand Gene (Faslg) Plays an Important Role in Nerve Degeneration and Regeneration After Rat Sciatic Nerve Injury.Frontiers in molecular neuroscience · 2018Article
- Critical signaling pathways during Wallerian degeneration of peripheral nerve.Neural regeneration research · 2017Article
- Mrpl10 and Tbp Are Suitable Reference Genes for Peripheral Nerve Crush Injury.International journal of molecular sciences · 2017Article
- Microarray and qPCR Analyses of Wallerian Degeneration in Rat Sciatic Nerves.Frontiers in cellular neuroscience · 2017Article
- Ingenuity Pathway Analysis of Gene Expression Profiles in Distal Nerve Stump following Nerve Injury: Insights into Wallerian Degeneration.Frontiers in cellular neuroscience · 2016Article
- Follow-up evaluation with ultrasonography of peripheral nerve injuries after an earthquake.Neural regeneration research · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wallerian degeneration is an important area of research in modern neuroscience. A large number of genes are differentially regulated in the various stages of Wallerian degeneration, especially during the early response. In this study, we analyzed gene expression in early Wallerian degeneration of the distal nerve stump at 0, 0.5, 1, 6, 12 and 24 hours after rat sciatic nerve injury using gene chip microarrays. We screened for differentially-expressed genes and gene expression patterns. We examined the data for Gene Ontology, and explored the Kyoto Encyclopedia of Genes and Genomes Pathway. This allowed us to identify key regulatory factors and recurrent network motifs. We identified 1 546 differentially-expressed genes and 21 distinct patterns of gene expression in early Wallerian degeneration, and an enrichment of genes associated with the immune response, acute inflammation, apoptosis, cell adhesion, ion transport and the extracellular matrix. Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed components involved in the Jak-STAT, ErbB, transforming growth factor-β, T cell receptor and calcium signaling pathways. Key factors included interleukin-6, interleukin-1, integrin, c-sarcoma, carcinoembryonic antigen-related cell adhesion molecules, chemokine (C-C motif) ligand, matrix metalloproteinase, BH3 interacting domain death agonist, baculoviral IAP repeat-containing 3 and Rac. The data were validated with real-time quantitative PCR. This study provides a global view of gene expression profiles in early Wallerian degeneration of the rat sciatic nerve. Our findings provide insight into the molecular mechanisms underlying early Wallerian degeneration, and the regulation of nerve degeneration and regeneration.
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