Evidence map›Paper›PMID 25657646›Full record

ReviewFrontiers in immunology2014

Ontogeny and polarization of macrophages in inflammation: blood monocytes versus tissue macrophages.

Adwitia Dey, Joselyn Allen, Pamela A Hankey-Giblin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  8. Tissue signatures of human macrophages during homeostasis and activation.Journal of immunology (Baltimore, Md. : 1950) · 2026
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adwitia DeyDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, PA , USA ; Graduate Program in Physiology, The Pennsylvania State University , University Park, PA , USA.
Joselyn AllenDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, PA , USA ; Graduate Program in Immunology and Infectious Disease, The Pennsylvania State University , University Park, PA , USA.
Pamela A Hankey-GiblinDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, PA , USA ; Graduate Program in Physiology, The Pennsylvania State University , University Park, PA , USA ; Graduate Program in Immunology and Infectious Disease, The Pennsylvania State University , University Park, PA , USA.

Funding

Research Training in Physiological Adaptations to StressT32GM108563 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, KORZICK, DONNA HOPE · 2014 to 2023
$2.2M
NIGMS NIH HHS T32 GM108563
6 · The paper itself

Abstract

The explosion of new information in recent years on the origin of macrophages in the steady-state and in the context of inflammation has opened up numerous new avenues of investigation and possibilities for therapeutic intervention. In contrast to the classical model of macrophage development, it is clear that tissue-resident macrophages can develop from yolk sac-derived erythro-myeloid progenitors, fetal liver progenitors, and bone marrow-derived monocytes. Under both homeostatic conditions and in response to pathophysiological insult, the contribution of these distinct sources of macrophages varies significantly between tissues. Furthermore, while all of these populations of macrophages appear to be capable of adopting the polarized M1/M2 phenotypes, their respective contribution to inflammation, resolution of inflammation, and tissue repair remains poorly understood and is likely to be tissue- and disease-dependent. A better understanding of the ontology and polarization capacity of macrophages in homeostasis and disease will be essential for the development of novel therapies that target the inherent plasticity of macrophages in the treatment of acute and chronic inflammatory disease.

Indexed as

adipose tissue macrophageshepatic steatosisKupffer cellsM1M2microglianeurodegenerative diseaseobesitytissue-resident macrophages

Identifiers

PMID25657646
PMCPMC4303141

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.