ReviewJournal of conservative dentistry : JCD
Current overview on challenges in regenerative endodontics.
Review in Journal of conservative dentistry : JCD. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Clinical, radiographic, and biomarker perspectives of low-level laser therapy during regenerative endodontic procedures in necrotic immature young teeth: a randomized clinical study.Lasers in medical science · 2025Trial
- Noncoding RNA networks in endodontic regeneration: Current evidence and future directions.Journal of conservative dentistry and endodontics · 2026Review
- Outcome evaluation of regenerative endodontic therapy using injectable-platelet-rich fibrin and platelet-rich fibrin in nonvital immature permanent teeth: A prospective observational study.Journal of conservative dentistry and endodontics · 2026Article
- Article
- Human amniotic membrane as an extracellular matrix scaffold in regenerative endodontics: A cell homing perspective.Journal of conservative dentistry and endodontics · 2026Review
- Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.Probiotics and antimicrobial proteins · 2026Review
- Long-term Outcome of Vital Pulp Therapy and Regenerative Endodontic Procedures in Immature Permanent Maxillary Incisors: A 7-year Follow-up Case Report.International journal of clinical pediatric dentistry · 2026Article
- Effects of combining hyaluronic acid hydrogel with injectable platelet rich fibrin on apical papilla stem cells proliferation and differentiation.BMC oral health · 2025Article
- Regenerative Endodontic Therapies: Harnessing Stem Cells, Scaffolds, and Growth Factors.Polymers · 2025Review
- Effect of continuous chelation irrigation on transforming growth factor-β1 release: AnJournal of conservative dentistry and endodontics · 2025Article
- Advent of novel vehicle in regenerative endodontics and its effect on dentinal penetration of intracanal medicaments.Journal of conservative dentistry and endodontics · 2024Article
- Comparison of double antibiotic chitosan hydrogel scaffold with platelet-rich fibrin in regeneration in immature necrotic permanent teeth - Randomized controlled trial.Journal of conservative dentistry and endodontics · 2024Article
- Enriched advanced platelet-rich fibrin plus gold nanoparticles againstJournal of conservative dentistry and endodontics · 2024Article
- A comparative clinico-radiographic analysis of regenerative endodontic procedure on immature necrotic permanent teeth using blood clot and PRF as scaffold: A retrospective study.The Saudi dental journal · 2023Article
- Effect of Hydroxyapatite Microspheres, Amoxicillin-Hydroxyapatite and Collagen-Hydroxyapatite Composites on Human Dental Pulp-Derived Mesenchymal Stem Cells.Materials (Basel, Switzerland) · 2021Article
- Evaluating the potential of an amelogenin-derived peptide in tertiary dentin formation.Regenerative biomaterials · 2021Article
- Antimicrobial Therapeutics in Regenerative Endodontics: A Scoping Review.Journal of endodontics · 2020Article
- Platelet-rich fibrin and collagen matrix for the regeneration of infected necrotic immature teeth.Journal of clinical and translational research · 2020Article
- In vitro response of dental pulp stem cells in 3D scaffolds: A regenerative bone material.Heliyon · 2018Article
- Factors that cause endodontic failures in general practices in Japan.BMC oral health · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRegenerative endodontics provides hope of converting the non-vital tooth into vital once again. It focuses on substituting traumatized and pathological pulp with functional pulp tissue. Current regenerative procedures successfully produce root development but still fail to re-establish real pulp tissue and give unpredictable results. There are several drawbacks that need to be addressed to improve the quality and efficiency of the treatment.
aimThe aim of this review article is to discuss major priorities that ought to be dealt before applications of regenerative endodontics flourish the clinical practice. MATERIALS AND
methodsA web-based research on MEDLINE was done using filter terms Review, published in the last 10 years and Dental journals. Keywords used for research were "regenerative endodontics," "dental stem cells," "growth factor regeneration," "scaffolds," and "challenges in regeneration." This review article screened about 150 articles and then the relevant information was compiled.
resultsInspite of the impressive growth in regenerative endodontic field, there are certain loopholes in the existing treatment protocols that might sometimes result in undesired and unpredictable outcomes.
conclusionConsiderable research and development efforts are required to improve and update existing regenerative endodontic strategies to make it an effective, safe, and biological mode to save teeth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.