Evidence map›Paper›PMID 25657347›Full record

ReviewGenetics2015

Brainbow: new resources and emerging biological applications for multicolor genetic labeling and analysis.

Tamily A Weissman, Y Albert Pan

Abstract readReview
In one paragraph

Review in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

  1. Article
  2. Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026
    Review
  3. Review
  4. OPTRACE: Optical Imaging-Guided Transplantation and Tracking of Cells in the Mouse Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. Deciphering precursor cell dynamics in esophageal preneoplasia via genetic barcoding and single-cell transcriptomics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Clonal tracking in cancer and metastasis.Cancer metastasis reviews · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tamily A WeissmanDepartment of Biology, Lewis and Clark College, Portland, Oregon 97219 weissman@Lclark.edu ypan@gru.edu.
Y Albert PanDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912 Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912 James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912 weissman@Lclark.edu ypan@gru.edu.

Funding

Multicolor Fluorescent Analysis in ZebrafishR01HD067140 · NICHD · HARVARD UNIVERSITY · PI SCHIER, ALEXANDER F · 2010 to 2012
$713k
NICHD NIH HHS R01 HD067140NICHD NIH HHS R01HD067140
6 · The paper itself

Abstract

Brainbow is a genetic cell-labeling technique where hundreds of different hues can be generated by stochastic and combinatorial expression of a few spectrally distinct fluorescent proteins. Unique color profiles can be used as cellular identification tags for multiple applications such as tracing axons through the nervous system, following individual cells during development, or analyzing cell lineage. In recent years, Brainbow and other combinatorial expression strategies have expanded from the mouse nervous system to other model organisms and a wide variety of tissues. Particularly exciting is the application of Brainbow in lineage tracing, where this technique has been instrumental in parsing out complex cellular relationships during organogenesis. Here we review recent findings, new technical improvements, and exciting potential genetic and genomic applications for harnessing this colorful technique in anatomical, developmental, and genetic studies.

Indexed as

AnimalsAnimals, Genetically ModifiedCell TrackingGene ExpressionGenetic EngineeringGenetic VectorsGene Transfer TechniquesHumansLuminescent ProteinsModels, AnimalLuminescent Proteinsclonal analysisfluorescence microscopyin vivo imaginglineage tracingneural circuitry

Identifiers

PMID25657347
PMCPMC4317644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.