ArticleMolecular biology of the cell2015
Thyroid hormone signaling controls hair follicle stem cell function.
Article in Molecular biology of the cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03602534 (Thyroid Dysfunction in Female Patients With Acne Vulgaris), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Thyroid Dysfunction in Female Patients With Acne Vulgaris: [ Relation to Other Variables ]
Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Deciphering cysteamine's impact on cashmere-producing traits of cashmere goats: a transcriptomic and metabolomic perspective.Frontiers in veterinary science · 2026Article
- Recent Advances in Drug Development for Hair Loss.International journal of molecular sciences · 2025Review
- Association between non-scarring alopecia and hypothyroidism: a bidirectional two-sample Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Article
- Dictys: dynamic gene regulatory network dissects developmental continuum with single-cell multiomics.Nature methods · 2023Article
- Study of the Thyroid Profile of Patients with Alopecia.Journal of clinical medicine · 2023Review
- Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss.Journal of clinical medicine · 2023Review
- The thyroid hormone enhances mouse embryonic fibroblasts reprogramming to pluripotent stem cells: role of the nuclear receptor corepressor 1.Frontiers in endocrinology · 2023Article
- Application of lncRNA-miRNA-mRNA ceRNA network analysis in the treatment of androgenic alopecia.Journal of clinical laboratory analysis · 2023Article
- Mendelian randomization study highlights hypothyroidism as a causal determinant of alopecia areata.Frontiers in endocrinology · 2023Article
- Dermoscopic Findings of Alopecia in Patients with Hypothyroidism.International journal of endocrinology and metabolism · 2022Article
- Thyroid Hormone Receptor Agonist Promotes Hair Growth in Mice.Clinical, cosmetic and investigational dermatology · 2022Article
- Proteomics changes after negative pressure wound therapy in diabetic foot ulcers.Molecular medicine reports · 2021Article
- Novel rhino-like SHJHZoological research · 2021Article
- Thyroid hormone action in epidermal development and homeostasis and its implications in the pathophysiology of the skin.Journal of endocrinological investigation · 2021Review
- Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?Experimental dermatology · 2020Review
- Alcohol extract from Vernonia anthelmintica willd (L.) seed counteracts stress-induced murine hair follicle growth inhibition.BMC complementary and alternative medicine · 2019Article
- Screening Guidelines for Thyroid Function in Children With Alopecia Areata.JAMA dermatology · 2017Article
- Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from theCurrent stem cell reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Observations in thyroid patients and experimental animals show that the skin is an important target for the thyroid hormones. We previously showed that deletion in mice of the thyroid hormone nuclear receptors TRα1 and TRβ (the main thyroid hormone-binding isoforms) results in impaired epidermal proliferation, hair growth, and wound healing. Stem cells located at the bulges of the hair follicles are responsible for hair cycling and contribute to the regeneration of the new epidermis after wounding. Therefore a reduction in the number or function of the bulge stem cells could be responsible for this phenotype. Bulge cells show increased levels of epigenetic repressive marks, can retain bromodeoxyuridine labeling for a long time, and have colony-forming efficiency (CFE) in vitro. Here we demonstrate that mice lacking TRs do not have a decrease of the bulge stem cell population. Instead, they show an increase of label-retaining cells (LRCs) in the bulges and enhanced CFE in vitro. Reduced activation of stem cells leading to their accumulation in the bulges is indicated by a strongly reduced response to mobilization by 12-O-tetradecanolyphorbol-13-acetate. Altered function of the bulge stem cells is associated with aberrant activation of Smad signaling, leading to reduced nuclear accumulation of β-catenin, which is crucial for stem cell proliferation and mobilization. LRCs of TR-deficient mice also show increased levels of epigenetic repressive marks. We conclude that thyroid hormone signaling is an important determinant of the mobilization of stem cells out of their niche in the hair bulge. These findings correlate with skin defects observed in mice and alterations found in human thyroid disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.