Evidence map›Paper›PMID 25657192›Full record

ArticleAmerican journal of men's health2016

Racial Differences in Diffusion of Intensity-Modulated Radiation Therapy for Localized Prostate Cancer.

Ewan K Cobran, Ronald C Chen, Robert Overman, Anne-Marie Meyer, Tzy-Mey Kuo, Jonathon O'Brien, Til Sturmer, Nathan C Sheets, Gregg H Goldin, Dolly C Penn and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of men's health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Ewan K CobranUniversity of Georgia, College of Pharmacy, Athens, GA, USA ecobran@uga.edu.
Ronald C ChenUniversity of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, USA.
Robert OvermanUNC, Eshelman School of Pharmacy, Chapel Hill, NC, USA.
Anne-Marie MeyerUNC, Gillings School of Global Public Health, Chapel Hill, NC, USA.
Tzy-Mey KuoUNC, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.
Jonathon O'BrienUNC, Gillings School of Global Public Health, Chapel Hill, NC, USA.
Til SturmerUNC, Gillings School of Global Public Health, Chapel Hill, NC, USA.
Nathan C SheetsUniversity of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, USA.
Gregg H GoldinUniversity of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, USA.
Dolly C PennUniversity of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, USA.
Paul A GodleyUniversity of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, USA.
William R CarpenterUNC, Gillings School of Global Public Health, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USGeorgia College & State University · USUNC Lineberger Comprehensive Cancer CenterUniversity of North Carolina Health Care · US

Funding

CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVIDIAN, MARIE, KOSOROK, MICHAEL R · 2010 to 2019
$21.3M
UNC Clinical and Translational Science AwardUL1TR000083 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2012 to 2013
$11.6M
Training ProgramU54CA153602 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GODLEY, PAUL A. · 2010 to 2015
$5.4M
Biostatistics for Research in Genomics and CancerT32CA106209 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOSEPH G IBRAHIM, Naim Ur Rashid · 2004 to 2026
$4.8M
Increasing Cancer Clinical Trial Enrollment in North Carolina CommunitiesU01CA114629 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GODLEY, PAUL A. · 2005 to 2009
$4.2M
Cancer Health Disparities Training ProgramT32CA128582 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ENG, EUGENIA, TATE, DEBORAH F. · 2009 to 2023
$3.4M
Implementing Systemic Interventions to Close the Discovery-Delivery GapR01CA124402 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINER, BRYAN J. · 2007 to 2012
$2.8M
Academic Training in Oncology at the University of North Carolina at Chapel HillT32CA128590 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CAREY, LISA A · 2008 to 2012
$1.2M
NCATS NIH HHS UL1 TR000083NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261200800726PNCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS P01 CA142538NCI NIH HHS R01 CA124402NCI NIH HHS T32 CA106209NCI NIH HHS T32 CA128582NCI NIH HHS T32 CA128590NCI NIH HHS U01 CA114629NCI NIH HHS U54 CA153602
6 · The paper itself

Abstract

Intensity-modulated radiation therapy (IMRT), an innovative treatment option for prostate cancer, has rapidly diffused over the past decade. To inform our understanding of racial disparities in prostate cancer treatment and outcomes, this study compared diffusion of IMRT in African American (AA) and Caucasian American (CA) prostate cancer patients during the early years of IMRT diffusion using the Surveillance, Epidemiology and End Results (SEER)-Medicare linked database. A retrospective cohort of 947 AA and 10,028 CA patients diagnosed with localized prostate cancer from 2002 through 2006, who were treated with either IMRT or non-IMRT as primary treatment within 1 year of diagnoses was constructed. Logistic regression was used to examine potential differences in diffusion of IMRT in AA and CA patients, while adjusting for socioeconomic and clinical covariates. A significantly smaller proportion of AA compared with CA patients received IMRT for localized prostate cancer (45% vs. 53%, p < .0001). Racial differences were apparent in multivariable analysis though did not achieve statistical significance, as time and factors associated with race (socioeconomic, geographic, and tumor related factors) explained the preponderance of variance in use of IMRT. Further research examining improved access to innovative cancer treatment and technologies is essential to reducing racial disparities in cancer care.

Indexed as

Radiotherapy, Intensity-ModulatedAgedBlack or African AmericanHumansLogistic ModelsMaleProstatic NeoplasmsRetrospective StudiesSEER ProgramUnited StatesWhite PeoplediffusionEpidemiology and End Results (SEER)–Medicareintensity-modulated radiation therapy (IMRT)radiation therapySurveillance

Identifiers

PMID25657192
PMCPMC4570865
OpenAlexW2111317639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.