ArticleNeurochemical research2015
Role of group II metabotropic glutamate receptors (mGluR2/3) blockade on long-term potentiation in the dentate gyrus region of hippocampus in rats fed with high-fat diet.
Article in Neurochemical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Review
- Cognitive Impairment and Synaptic Dysfunction in Cardiovascular Disorders: The New Frontiers of the Heart-Brain Axis.Biomedicines · 2024Review
- Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on hippocampal long-term potentiation at perforant pathway-dentate gyrus synapses in prenatal valproic acid-induced rat model of autism.Scientific reports · 2024Article
- Effect of intrahippocampal microinjection of VU0155041, a positive allosteric modulator of mGluR4, on long term potentiation in a valproic acid-induced autistic male rat model.IBRO neuroscience reports · 2024Article
- The effects of carvacrol and p-cymene on AβCNS neuroscience & therapeutics · 2024Article
- STalign: Alignment of spatial transcriptomics data using diffeomorphic metric mapping.Nature communications · 2023Article
- Alignment of spatial transcriptomics data using diffeomorphic metric mapping.bioRxiv : the preprint server for biology · 2023Article
- Effects of sesamin on AβMetabolic brain disease · 2023Article
- Neuroprotective effects of vinpocetine, as a phosphodiesterase 1 inhibitor, on long-term potentiation in a rat model of Alzheimer's disease.BMC neuroscience · 2023Article
- Impairment in social interaction and hippocampal long-term potentiation at perforant pathway-dentate gyrus synapses in a prenatal valproic acid-induced rat model of autism.Brain communications · 2022Article
- Memory and eating: A bidirectional relationship implicated in obesity.Neuroscience and biobehavioral reviews · 2022Review
- Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats.Behavioral and brain functions : BBF · 2021Article
- Effects of the hydroalcoholic extract of Rosa damascena on hippocampal long-term potentiation in rats fed high-fat diet.The journal of physiological sciences : JPS · 2021Article
- The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats.BMC neuroscience · 2021Article
- The effect of the mGlu8 receptor agonist, (S)-3,4-DCPG on acquisition and expression of morphine-induced conditioned place preference in male rats.Behavioral and brain functions : BBF · 2021Article
- Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet.IBRO reports · 2020Article
- Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats.IBRO reports · 2019Article
- Effect of garlic powder on hippocampal long-term potentiation in rats fed high fat diet: an in vivo study.Metabolic brain disease · 2018Article
- The effect of chronic stimulation of serotonin receptor type 7 on recognition, passive avoidance memory, hippocampal long-term potentiation, and neuronal apoptosis in the amyloid β protein treated rat.Psychopharmacology · 2018Article
- Effects of the hydroalcoholic extract of Rosa damascena on learning and memory in male rats consuming a high-fat diet.Pharmaceutical biology · 2017Article
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5 authors.
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Abstract
In the hippocampus, metabotropic glutamate receptors (mGluRs) are involved in various forms of synaptic plasticity. High-fat diets (HFDs) adversely influence hippocampal structure and function and induce changes in hippocampal glutamate metabolism and neurotransmission. Here, we studied the induction of hippocampal long-term potentiation (LTP) while blocking group II mGluR2/3. Thirty-two male Wistar rats were assigned into four groups: a control group that consumed an ordinary diet; a HFD group that ate a HFD; "HFD plus LY341495" ate a HFD and later received a selective group II metabotropic glutamate receptor antagonist; and "Control plus LY341495" group. After 6 months on the specified diet, the rats were anesthetized with intraperitoneal injection of ketamine and xylazin, and placed in a stereotaxic apparatus for surgery, electrode implantation, and field potential recording. We microinjected LY341495 solution unilaterally into the dentate gyrus (DG) to block mGluR2/3. The population spike (PS) amplitude and slope of excitatory post synaptic potentials (EPSP) were measured in the DG area in response to stimulation applied to the perforant pathway (400 Hz tetanization). We found that, after tentanizing the perforant pathway to induce LTP, HFD decreased PS amplitude and slope of EPSP compared to controls. Moreover, blocking group II mGluRs increased LTP not only in controls, but also in rats fed on HFD. Therefore, our results show that LY341495 rescues hippocampal synaptic plasticity that can be impaired by a HFD. In summary, these results indicate that mGluR2/3 inhibition may have stimulatory effects on LTP induction in the DG.
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