SynthesisInfection2015
Antimicrobial lock therapy in central-line associated bloodstream infections: a systematic review.
Synthesis in Infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Ethanol locks for the prevention of catheter-related bloodstream infection: a meta-analysis of randomized control trials.BMC anesthesiology · 2018Pooled it
- Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens.Pathogens (Basel, Switzerland) · 2024Review
- Antibiotic lock solutions as adjunct therapy for catheter-related blood stream infections in pediatric hemodialysis patients.Frontiers in pediatrics · 2024Review
- Effectiveness of Antimicrobial Lock Therapy for the Treatment of Catheter-Related and Central-Line-Associated Bloodstream Infections in Children: A Single Center Retrospective Study.Antibiotics (Basel, Switzerland) · 2023Article
- Article
- Biofilms by bacterial human pathogens: Clinical relevance - development, composition and regulation - therapeutical strategies.Microbial cell (Graz, Austria) · 2021Review
- Minimising Blood Stream Infection: Developing New Materials for Intravascular Catheters.Medicines (Basel, Switzerland) · 2020Review
- Antimicrobial Lock Therapy in Clinical Practice: A Scoping Review Protocol.Methods and protocols · 2020Article
- Review
- Chlorhexidine locking device for central line infection prevention in ICU patients: protocol for an open-label pilot and feasibility randomized controlled trial.Pilot and feasibility studies · 2020Article
- Dose-Dependent Synergistic Interactions of Colistin with Rifampin, Meropenem, and Tigecycline against Carbapenem-Resistant Klebsiella pneumoniae Biofilms.Antimicrobial agents and chemotherapy · 2019Article
- Is heparinized 40% ethanol lock solution efficient for reducing bacterial and fungal biofilms in an in vitro model?PloS one · 2019Article
- Antimicrobial Efficacy and Safety of a Novel Gas Plasma-Activated Catheter Lock Solution.Antimicrobial agents and chemotherapy · 2018Article
- Pre-emptive Intestinal Transplant: The Surgeon's Point of View.Digestive diseases and sciences · 2017Review
- Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis.PLoS pathogens · 2017Article
- Microbial Biofilms in Pulmonary and Critical Care Diseases.Annals of the American Thoracic Society · 2016Review
- Surveillance of bloodstream infections in pediatric cancer centers - what have we learned and how do we move on?GMS hygiene and infection control · 2016Review
- Tigecycline Lock Therapy for Catheter-Related Bloodstream Infection Caused by KPC-Producing Klebsiella pneumoniae in Two Pediatric Hematological Patients.Antimicrobial agents and chemotherapy · 2015Article
- The Antiseptic and Antineoplastic Agent Taurolidine Modulates Key Leukocyte Functions.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAntimicrobial lock therapy (ALT) seems a promising approach for treatment of central line associated bloodstream infections (CLABSI). The recent introduction of molecules such as daptomycin and tigecycline, alone or in combination with other molecules, improved chances of efficacy of ALT, due to their activity on the bacterial biofilm. Our aim was to review the literature concerning ALT for CLABSI, including data concerning novel molecules.
methodsWe included case-control studies evaluating two or more molecules as ALT in central venous catheter infections extracted from the Medline database. Among 221 available articles in Pubmed, 54 were selected for their particular interest concerning ALT.
resultsIncidence of CLABSI is high worldwide. Mechanisms of catheter infection include contamination by skin bacteria, hand contamination and hematogenous diffusion. Catheter-infection is associated with biofilm formation, which reduces the efficacy of ALT. The most promising situation for ALT to succeed in salvaging a catheter appears to be coagulase-negative Staphylococcus infection, which is the main causative agent of CLABSI. Daptomycin, Tigecycline, Ethanol and Taurolidine appear as the best options for treating CLABSI; data are mostly available for Daptomycin, which showed, alone or associated with Rifampin, good in vitro potency on biofilm, but few in vivo data exist on efficacy.
conclusionsThe introduction of novel molecules has increased chances of catheter salvage with ALT in case of CLABSI, but further in vivo studies are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.