ArticleThe Journal of biological chemistry2015
Inhibition of Anopheles gambiae odorant receptor function by mosquito repellents.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- In vitro larvicidal activity of selected azabenzimidazole and diarylquinoline derivatives against Anopheles gambiae and in silico mechanistic analysis.Molecular diversity · 2026Article
- A critical review of current laboratory methods used to evaluate mosquito repellents.Frontiers in insect science · 2024Review
- Article
- Cellular and molecular mechanisms of DEET toxicity and disease-carrying insect vectors: a review.Genes & genomics · 2020Review
- The Emergence of Insect Odorant Receptor-Based Biosensors.Biosensors · 2020Review
- Odor coding of nestmate recognition in the eusocial antThe Journal of experimental biology · 2020Article
- Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit.Scientific reports · 2019Article
- Odorant Receptors and Odorant-Binding Proteins as Insect Pest Control Targets: A Comparative Analysis.Frontiers in physiology · 2018Review
- Essential Oils as Repellents against Arthropods.BioMed research international · 2018Review
- Molecular Basis of N,N-Diethyl-3-Methylbenzamide (DEET) in Repelling the Common Bed Bug,Frontiers in physiology · 2017Article
- Inhibition of insect olfactory behavior by an airborne antagonist of the insect odorant receptor co-receptor subunit.PloS one · 2017Article
- The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells.Scientific reports · 2016Article
- Bitter-sensitive gustatory receptor neuron responds to chemically diverse insect repellents in the common malaria mosquito Anopheles quadrimaculatus.Die Naturwissenschaften · 2016Article
- Positive Allosteric Modulation of Insect Olfactory Receptor Function by ORco Agonists.Frontiers in cellular neuroscience · 2016Article
- Neuroethology of Olfactory-Guided Behavior and Its Potential Application in the Control of Harmful Insects.Frontiers in physiology · 2016Review
- Review
- Volatile allosteric antagonists of mosquito odorant receptors inhibit human-host attraction.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of molecular targets of insect repellents has been a challenging task, with their effects on odorant receptors (ORs) remaining a debatable issue. Here, we describe a study on the effects of selected mosquito repellents, including the widely used repellent N,N-diethyl-meta-toluamide (DEET), on the function of specific ORs of the African malaria vector Anopheles gambiae. This study, which has been based on quantitative measurements of a Ca(2+)-activated photoprotein biosensor of recombinant OR function in an insect cell-based expression platform and a sequential compound addition protocol, revealed that heteromeric OR (ORx/Orco) function was susceptible to strong inhibition by all tested mosquito repellents except DEET. Moreover, our results demonstrated that the observed inhibition was due to efficient blocking of Orco (olfactory receptor coreceptor) function. This mechanism of repellent action, which is reported for the first time, is distinct from the mode of action of other characterized insect repellents including DEET.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.