ArticleExpert review of vaccines2015
IL-33 isoforms: their future as vaccine adjuvants?
Article in Expert review of vaccines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Association between short-term exposure to ambient ozone concentration and influenza incidence in Kawasaki City, Japan: a time-stratified case-crossover analysis.BMC public health · 2025Article
- Interleukins in the Pathogenesis of Warts: Insight from the Last Decade-A Narrative Review.Journal of clinical medicine · 2025Review
- The ambient ozone and COVID-19 transmissibility in China: A data-driven ecological study of 154 cities.The Journal of infection · 2020Article
- Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection fromVaccines · 2020Article
- IL-33 Alarmin and Its Active Proinflammatory Fragments Are Released in Small Intestine in Celiac Disease.Frontiers in immunology · 2020Article
- Anti-Tumorigenic Activities of IL-33: A Mechanistic Insight.Frontiers in immunology · 2020Review
- Ambient ozone and influenza transmissibility in Hong Kong.The European respiratory journal · 2018Article
- The Pro-tumorigenic IL-33 Involved in Antitumor Immunity: A Yin and Yang Cytokine.Frontiers in immunology · 2018Review
- The Pleiotropic Immunomodulatory Functions of IL-33 and Its Implications in Tumor Immunity.Frontiers in immunology · 2018Review
- M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection.Scientific reports · 2017Article
- The Dynamic Role of the IL-33/ST2 Axis in Chronic Viral-infections: Alarming and Adjuvanting the Immune Response.EBioMedicine · 2016Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The identification and characterization of cytokine isoforms is likely to provide critical important new insight into immunobiology. Cytokine isoforms can provide additional diversity to their complex biological effects that participate in control and protection against different foreign pathogens. Recently, IL-33 has been identified as a proinflammatory cytokine having several different biologically active isoform products. Originally associated with Th2 immunity, new evidence now supports the role of two IL-33 isoforms to facilitate the generation of protective Th1 and CD8 T cell immunity against specific pathogens. Therefore, a better understanding of the IL-33 isoforms will inform us on how to utilize them to facilitate their development as tools as vaccine adjuvants for immune therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.