ArticleJournal of cellular and molecular medicine2015
LRP5 deficiency down-regulates Wnt signalling and promotes aortic lipid infiltration in hypercholesterolaemic mice.
Article in Journal of cellular and molecular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- The relationship between OPLL and metabolic disorders.Bone research · 2025Review
- Reduced Growth and Inflammation in Lrp5Journal of cellular and molecular medicine · 2025Article
- Unique Splicing ofInternational journal of molecular sciences · 2024Article
- Significance of the Wnt signaling pathway in coronary artery atherosclerosis.Frontiers in cardiovascular medicine · 2024Article
- Roles of pyroptosis and immune infiltration in aortic dissection.Frontiers in molecular biosciences · 2024Article
- The Contribution of Wnt Signaling to Vascular Complications in Type 2 Diabetes Mellitus.International journal of molecular sciences · 2022Review
- LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway.Journal of cellular and molecular medicine · 2022Article
- Inhibition of microRNA-494-3p activates Wnt signaling and reduces proinflammatory macrophage polarization in atherosclerosis.Molecular therapy. Nucleic acids · 2021Article
- LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium.International journal of molecular sciences · 2021Article
- Ckip-1 regulates C3H10T1/2 mesenchymal cell proliferation and osteogenic differentiation via Lrp5.Experimental and therapeutic medicine · 2021Article
- Wnt Signaling Cascades and Their Role in Coronary Artery Health and Disease.Journal of cellular signaling · 2021Article
- The role of Wnt signalling in development of coronary artery disease and its risk factors.Open biology · 2020Review
- Lipoprotein receptor signalling in atherosclerosis.Cardiovascular research · 2020Review
- CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninJournal of lipid research · 2019Article
- Macrophages as a Source and Recipient of Wnt Signals.Frontiers in immunology · 2019Review
- GSK3β inhibition and canonical Wnt signaling in mice hearts after myocardial ischemic damage.PloS one · 2019Article
- Clinical advantages and disadvantages of anabolic bone therapies targeting the WNT pathway.Nature reviews. Endocrinology · 2018Review
- Myeloid β-Catenin Deficiency Exacerbates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- WNT Signaling in Cardiac and Vascular Disease.Pharmacological reviews · 2018Review
- Wnt signaling in cardiovascular disease: opportunities and challenges.Current opinion in lipidology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low-density lipoprotein receptor-related protein 5 (LRP5) is a member of the LDLR family that orchestrates cholesterol homoeostasis. The role of LRP5 and the canonical Wnt pathway in the vascular wall of dyslipidaemic animals remains unknown. In this study, we analysed the role of LRP5 and the Wnt signalling pathway in mice fed a hypercholesterolaemic diet (HC) to trigger dyslipidaemia. We show that Lrp5(-/-) mice had larger aortic lipid infiltrations than wild-type mice, indicating a protective role for LRP5 in the vascular wall. Three members of the LDLR family, Lrp1, Vldlr and Lrp6, showed up-regulated gene expression levels in aortas of Lrp5(-/-) mice fed a hypercholesterolaemic diet. HC feeding in Lrp5(-/-) mice induced higher macrophage infiltration in the aortas and accumulation of inflammatory cytokines in blood. Wnt/β-CATENIN signalling proteins were down-regulated in HC Lrp5(-/-) mice indicating that LRP5 regulates the activation of Wnt signalling in the vascular wall. In conclusion, our findings show that LRP5 and the canonical Wnt pathway down-regulation regulate the dyslipidaemic profile by promoting lipid and macrophage retention in the vessel wall and increasing leucocyte-driven systemic inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.