ArticleBMC infectious diseases2015
Evaluation of a new, rapid, simple test for the detection of influenza virus.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Usefulness of rapid molecular tests in pediatric respiratory tract infections.Italian journal of pediatrics · 2022Article
- Improved performances of the second generation of the ID NOW influenza A&B 2® and comparison with the GeneXpert®.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Article
- Is there a clinical difference between influenza A and B virus infections in hospitalized patients? : Results after routine polymerase chain reaction point-of-care testing in the emergency room from 2017/2018.Wiener klinische Wochenschrift · 2019Article
- Review
- Evaluation of Seegene Allplex Respiratory Panel 1 kit for the detection of influenza virus and human respiratory syncytial virus.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2018Article
- Zoonotic Influenza and Human Health-Part 2: Clinical Features, Diagnosis, Treatment, and Prevention Strategies.Current infectious disease reports · 2018Review
- Profile of the Alere i Influenza A & B assay: a pioneering molecular point-of-care test.Expert review of molecular diagnostics · 2018Article
- A Rapid On-Site Assay for the Detection of Influenza A by Capillary Convective PCR.Molecular diagnosis & therapy · 2018Article
- Multicenter Clinical Evaluation of the Luminex Aries Flu A/B & RSV Assay for Pediatric and Adult Respiratory Tract Specimens.Journal of clinical microbiology · 2017Article
- Evaluation of Alere i RSV for Rapid Detection of Respiratory Syncytial Virus in Children Hospitalized with Acute Respiratory Tract Infection.Journal of clinical microbiology · 2017Article
- Erratum: Evaluation of a new, rapid, simple test for the detection of influenza virus.BMC infectious diseases · 2015Article
- Analytical performance of the Alere™ i Influenza A&B assay for the rapid detection of influenza viruses.Enfermedades infecciosas y microbiologia clinicaArticle
Corrections and comments
- Erratum issuedErratum: Evaluation of a new, rapid, simple test for the detection of influenza virus.2015 · Estape, Jordi Vila [corrected to Vila, Jordi]
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfluenza virus infections are responsible for significant morbidity and mortality in both pediatric and adult populations worldwide. Rapid and accurate diagnosis of influenza is necessary for appropriate patient management during the influenza season and for optimal utilization of anti-influenza therapy. We prospectively tested the accuracy of a simple and rapid diagnostic method.
methodsNinety-eight samples (nasal and pharyngeal swabs) from patients with upper respiratory tract infection symptoms who presented to primary healthcare centres in Barcelona (Spain) were prospectively analyzed. The samples were collected as part of influenza surveillance program. Samples that had enough volume to make the new test after aliquoting the amount needed to perform routine tests were included. None of the samples were pre-selected as a result of their status in relation to influenza virus. Samples were analyzed by in-house real-time PCR and Alere i Influenza A & B (Alere i), which uses isothermal amplification of nucleic acids for the qualitative detection of influenza A and B in nasal swabs transported in viral transport media. The two techniques were compared by positive percent agreement (PPA) and negative percent agreement (NPA). Statistical analysis was performed with Stata.
resultsOf the 98 samples analysed 90 were concordant; 46 (46.9%) were positive and 44 (44.9%) were negative. Five samples showed invalid results with the Alere i test and could be not re-tested due to insufficient sample volume and were not included in the final statistical analysis. In the 93 remaining samples, the Alere i test showed 97% of accuracy having correctly classified 90 samples. We obtained discordant results in 3 samples (3%). The PPA was 93.8% for influenza A and 94.1% for influenza B, and NPA was 100% for influenza A and influenza B virus. In addition, the Alere i was very rapid (15 minutes or less) and extremely easy to use.
conclusionsThe Alere i test provided a good correlation compared to the real-time PCR test for the diagnosis of influenza. Since this method can be performed in minutes, it allows immediate, accurate clinical decisions to prescribe appropriate antiviral treatment or isolation of patients.
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