ArticleBehavior genetics2015
Longitudinal development of hormone levels and grey matter density in 9 and 12-year-old twins.
Article in Behavior genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Gonadotropins Across the Lifespan: Their role in the Neurodevelopment-Neurodegeneration Continuum.The Yale journal of biology and medicine · 2026Review
- Predicting developmental norms from baseline cortical thickness in longitudinal studies.Biology of sex differences · 2026Article
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Machine Learning-Powered fNIRS Detection of Idiopathic Central Precocious Puberty via Prefrontal Cortex Activation.BME frontiers · 2026Article
- Regional gray matter volume is associated with motor imagery performance in children with and without developmental coordination disorder.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Disentangling the unique contributions of age, pubertal stage, and pubertal hormones to brain structure in childhood and adolescence.Developmental cognitive neuroscience · 2024Article
- Revisiting adolescence as a sensitive period for sociocultural processing.Neuroscience and biobehavioral reviews · 2024Review
- Diurnal Fluctuations in Steroid Hormones Tied to Variation in Intrinsic Functional Connectivity in a Densely Sampled Male.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Diurnal fluctuations in steroid hormones tied to variation in intrinsic functional connectivity in a densely sampled male.bioRxiv : the preprint server for biology · 2023Article
- Developmental brain changes during puberty and associations with mental health problems.Developmental cognitive neuroscience · 2023Article
- The role of puberty on physical and brain development: A longitudinal study in male Rhesus Macaques.Developmental cognitive neuroscience · 2023Article
- Effects of social rank and pubertal delay on brain structure in female rhesus macaques.Psychoneuroendocrinology · 2023Article
- Brain structure alterations in girls with central precocious puberty.Frontiers in neuroscience · 2023Article
- The effects of puberty and its hormones on subcortical brain development.Comprehensive psychoneuroendocrinology · 2021Article
- Calendar age and puberty-related development of regional gray matter volume and white matter tracts during adolescence.Brain structure & function · 2021Article
- The relationship between pubertal hormones and brain plasticity: Implications for cognitive training in adolescence.Developmental cognitive neuroscience · 2020Review
- Gray Matter Differences Between Premature Pubertal Girls With and Without the Reactivation of the Hypothalamic-Pituitary-Gonadal Axis.Frontiers in psychiatry · 2020Article
- Altered Brain Structure and Functional Connectivity Associated with Pubertal Hormones in Girls with Precocious Puberty.Neural plasticity · 2019Article
- Initiation of the Hypothalamic-Pituitary-Gonadal Axis in Young Girls Undergoing Central Precocious Puberty Exerts Remodeling Effects on the Prefrontal Cortex.Frontiers in psychiatry · 2019Article
- Impact of pubertal timing and depression on error-related brain activity in anxious youth.Developmental psychobiology · 2019Article
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Authors and funding
7 authors.
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Abstract
Puberty is characterized by major changes in hormone levels and structural changes in the brain. To what extent these changes are associated and to what extent genes or environmental influences drive such an association is not clear. We acquired circulating levels of luteinizing hormone, follicle stimulating hormone (FSH), estradiol and testosterone and magnetic resonance images of the brain from 190 twins at age 9 [9.2 (0.11) years; 99 females/91 males]. This protocol was repeated at age 12 [12.1 (0.26) years] in 125 of these children (59 females/66 males). Using voxel-based morphometry, we tested whether circulating hormone levels are associated with grey matter density in boys and girls in a longitudinal, genetically informative design. In girls, changes in FSH level between the age of 9 and 12 positively associated with changes in grey matter density in areas covering the left hippocampus, left (pre)frontal areas, right cerebellum, and left anterior cingulate and precuneus. This association was mainly driven by environmental factors unique to the individual (i.e. the non-shared environment). In 12-year-old girls, a higher level of circulating estradiol levels was associated with lower grey matter density in frontal and parietal areas. This association was driven by environmental factors shared among the members of a twin pair. These findings show a pattern of physical and brain development going hand in hand.
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