ArticleAJNR. American journal of neuroradiology2015
Disrupted resting-state functional connectivity in progressive supranuclear palsy.
Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characterisation of meta-analytical functional connectivity in progressive supranuclear palsy.Clinical radiology · 2018Pooled it
- Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy.Science advances · 2026Article
- Diagnostic utility of biomarkers in progressive supranuclear palsy: toward a biotyping framework.Journal of neurology · 2025Review
- Remote Cortical Network for Frontal Cognitive Symptoms Derived from Tau Accumulation in Progressive Supranuclear Palsy.bioRxiv : the preprint server for biology · 2025Article
- Resting-State Functional MRI Approaches to Parkinsonisms and Related Dementia.Current neurology and neuroscience reports · 2024Review
- Stepwise Functional Brain Architecture Correlates with Atrophy in Progressive Supranuclear Palsy.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Diagnosis and Management of Progressive Corticobasal Syndrome.Current treatment options in neurology · 2024Article
- Frontal hypometabolism in the diagnosis of progressive supranuclear palsy clinical variants.Journal of neurology · 2024Article
- C-STIM: Protocol for a randomized, single-blind, crossover study of cerebellar repetitive transcranial magnetic stimulation (rTMS) for postural instability in people with progressive supranuclear palsy (PSP).Contemporary clinical trials communications · 2023Article
- Pathomechanisms of cognitive impairment in progressive supranuclear palsy.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Interplay of tau and functional network connectivity in progressive supranuclear palsy: a [European journal of nuclear medicine and molecular imaging · 2022Article
- Multiscale Entropy of Resting-State Functional Magnetic Resonance Imaging Differentiates Progressive Supranuclear Palsy and Multiple System Atrophy.Life (Basel, Switzerland) · 2021Article
- Functional Connectome in Parkinson's Disease and Parkinsonism.Current neurology and neuroscience reports · 2021Review
- Salience driven attention is pivotal to understanding others' intentions.Cognitive neuropsychology · 2021Article
- Alexithymia and anhedonia in early Richardson's syndrome and progressive supranuclear palsy with predominant parkinsonism.Brain and behavior · 2019Article
- Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies.Brain : a journal of neurology · 2019Article
- Resting-state Functional MRI in Parkinsonian Syndromes.Movement disorders clinical practice · 2019Review
- Neuroimaging in aging and neurologic diseases.Handbook of clinical neurology · 2019Review
- Article
- Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?Movement disorders : official journal of the Movement Disorder Society · 2017Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeStudies on functional connectivity in progressive supranuclear palsy have been restricted to the thalamus and midbrain tegmentum. The present study aims to evaluate functional connectivity abnormalities of the subcortical structures in these patients. Functional connectivity will be correlated with motor and nonmotor symptoms of the disease. MATERIALS AND
methodsNineteen patients with progressive supranuclear palsy (mean age, 70.93 ± 5.19 years) and 12 age-matched healthy subjects (mean age, 69.17 ± 5.20 years) underwent multimodal MR imaging, including fMRI at rest, 3D T1-weighted imaging, and DTI. fMRI data were processed with fMRI of the Brain Software Library tools by using the dorsal midbrain tegmentum, thalamus, caudate nucleus, putamen, and pallidum as seed regions.
resultsPatients had lower functional connectivity than healthy subjects in all 5 resting-state networks, mainly involving the basal ganglia, thalamus, anterior cingulate, dorsolateral prefrontal and temporo-occipital cortices, supramarginal gyrus, supplementary motor area, and cerebellum. Compared with healthy subjects, patients also displayed subcortical atrophy and DTI abnormalities. Decreased thalamic functional connectivity correlated with clinical scores, as assessed by the Hoehn and Yahr Scale and by the bulbar and mentation subitems of the Progressive Supranuclear Palsy Rating Scale. Decreased pallidum functional connectivity correlated with lower Mini-Mental State Examination scores; decreased functional connectivity in the dorsal midbrain tegmentum network correlated with lower scores in the Frontal Assessment Battery.
conclusionsThe present study demonstrates a widespread disruption of cortical-subcortical connectivity in progressive supranuclear palsy and provides further insight into the pathophysiologic mechanisms of motor and cognitive impairment in this condition.
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