Evidence map›Paper›PMID 25655679›Full record

ArticleOsteoarthritis and cartilage2015

Intermittent applied mechanical loading induces subchondral bone thickening that may be intensified locally by contiguous articular cartilage lesions.

B Poulet, R de Souza, A V Kent, L Saxon, O Barker, A Wilson, Y-M Chang, M Cake, A A Pitsillides

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 79 citations in OpenAlex.

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  12. Small-Animal Compression Models of Osteoarthritis.Methods in molecular biology (Clifton, N.J.) · 2023
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  20. Macrophage phenotypes and monocyte subsets after destabilization of the medial meniscus in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

B PouletUniversity College London, Royal Free Campus, London, UK.
R de SouzaUniversidade Federal do Mato Grosso, Mato Grosso, Brazil.
A V KentRoyal Veterinary College, London, UK.
L SaxonRoyal Veterinary College, London, UK.
O BarkerRoyal Veterinary College, London, UK.
A WilsonRoyal Veterinary College, London, UK.
Y-M ChangRoyal Veterinary College, London, UK.
M CakeMurdoch University, Perth, Australia.
A A PitsillidesRoyal Veterinary College, London, UK. Electronic address: apitsillides@rvc.ac.uk.
Royal Veterinary College · GBMurdoch University · AUThe Royal Free Hospital · GBUniversidade Federal de Mato Grosso · BR

Funding

Arthritis Research UK 18768Arthritis Research UK 19770Arthritis Research UK 20258Arthritis Research UK 20581Versus Arthritis 18768Versus Arthritis 19770Versus Arthritis 20258
6 · The paper itself

Abstract

objectivesChanges in subchondral bone (SCB) and cross-talk with articular cartilage (AC) have been linked to osteoarthritis (OA). Using micro-computed tomography (micro-CT) this study: (1) examines changes in SCB architecture in a non-invasive loading mouse model in which focal AC lesions are induced selectively in the lateral femur, and (2) determines any modifications in the contralateral knee, linked to changes in gait, which might complicate use of this limb as an internal control.

methodsRight knee joints of CBA mice were loaded: once with 2 weeks of habitual use (n = 7), for 2 weeks (n = 8) or for 5 weeks (n = 5). Both left (contralateral) and right (loaded) knees were micro-CT scanned and the SCB and trabecular bone analysed. Gait analysis was also performed.

resultsThese analyses showed a significant increase in SCB thickness in the lateral compartments in joints loaded for 5 weeks, which was most marked in the lateral femur; the contralateral non-loaded knee also showed transient SCB thickening (loaded once and repetitively). Epiphyseal trabecular bone BV/TV and trabecular thickness were also increased in the lateral compartments after 5 weeks of loading, and in all joint compartments in the contralateral knee. Gait analysis showed that applied loading only affected gait in the contralateral himd-limb in all groups of mice from the second week after the first loading episode.

conclusionsThese data indicate a spatial link between SCB thickening and AC lesions following mechanical trauma, and the clear limitations associated with the use of contralateral joints as controls in such OA models, and perhaps in OA diagnosis.

Indexed as

AnimalsArthritis, ExperimentalCartilage, ArticularEpiphysesFemurGaitMaleMice, Inbred CBAMotor ActivityOsteoarthritisStress, MechanicalTibiaWeight-BearingX-Ray MicrotomographyArticular cartilageJointMechanical loadingSubchondral bone and osteoarthritis

Identifiers

PMID25655679
PMCPMC4459965
OpenAlexW2171245019

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.