Evidence map›Paper›PMID 25655671›Full record

ArticleBMC family practice2015

Prescription of antibiotics and anxiolytics/hypnotics to asthmatic patients in general practice: a cross-sectional study based on French and Italian prescribing data.

David Darmon, Laurent Laforest, Eric Van Ganse, Ferdinando Petrazzuoli, Chris van Weel, Laurent Letrilliart

Abstract read
In one paragraph

Article in BMC family practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Can eosinophilia and neutrophil-lymphocyte ratio predict hospitalization in asthma exacerbation?Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David DarmonDépartement d'enseignement et de recherche en médecine générale, Faculté de médecine, Université de Nice Sophia-Antipolis, 28 avenue Valombrose, 06 107, Nice, Cedex 02, France. david.darmon@unice.fr.
Laurent LaforestUnité de Pharmaco épidémiologie, Faculté d'Odontologie, UMR 5558 CNRS - Université Claude-Bernard Lyon, CHU, Lyon, France. laurent.laforest@univ-lyon1.fr.
Eric Van GanseUnité de Pharmaco épidémiologie, Faculté d'Odontologie, UMR 5558 CNRS - Université Claude-Bernard Lyon, CHU, Lyon, France. eric.van-ganse@univ-lyon1.fr.
Ferdinando PetrazzuoliSNAMID Caserta (Italian Society of General Practice), Caserta, Italy. ferdinando.petrazzuoli@gmail.com.
Chris van WeelDepartment of Primary and Community Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. C.vanWeel@elg.umcn.nl.
Laurent LetrilliartDépartement de médecine générale, Faculté de médecine, Université Claude-Bernard Lyon I, Lyon, France. laurent.letrilliart@wanadoo.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAsthma is often poorly controlled and guidelines are often inadequately followed in medical practice. In particular, the prescription of non-asthma-specific drugs can affect the quality of care. The goal of this study was to measure the frequency of the prescription of antibiotics and anxiolytics/hypnotics to asthmatic patients and to look for associations between sex or age and the prescription of these drugs.

methodsA cross-sectional study was conducted using computerised medical records from French and Italian general practitioners' networks. Patients were selected according to criteria adapted from the HEDIS (Healthcare Effectiveness Data and Information Set) criteria. The outcome measure was the number of antibiotics or anxiolytics/hypnotics prescriptions per patient in 1 year. Parallel multivariate models were developed.

resultsThe final sample included 3,093 French patients (mean age 27.6 years, 49.7% women) and 3,872 Italian patients (mean age 29.1 years, 48.7% women). In the univariate analysis, the French patients were prescribed fewer antibiotics than the Italian patients (37.1% vs. 42.2%, p < 0.00001) but more anxiolytics/hypnotics (17.8% vs. 6.9%, p < 0.0001). In the multivariate models, the female patients were more likely to receive antibiotics (odds ratio: 1.5 [1.3-1.7]) and anxiolytics/hypnotics (odds ratio: 1.8 [1.5-2.1]).

conclusionsThe prescription of antibiotics and anxiolytics/hypnotics to asthmatic patients is frequent, especially in women. Asthma guidelines should address this issue by referring to other guidelines covering the prescription of non-asthma-specific drugs, and alternative non-pharmacological interventions should be considered.

Indexed as

AdolescentAdultAnti-Anxiety AgentsAnti-Bacterial AgentsAsthmaCross-Sectional StudiesDatabases, FactualFemaleFranceHumansHypnotics and SedativesItalyMaleMultivariate AnalysisPractice Guidelines as TopicPractice Patterns, Physicians'Anti-Anxiety AgentsAnti-Bacterial AgentsHypnotics and Sedatives

Identifiers

PMID25655671
PMCPMC4326444

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.