ArticleJournal of the American Heart Association2015
Clinical correlates and prognostic significance of change in standardized left ventricular mass in a community-based cohort of African Americans.
Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Prediction of cardiovascular adverse events in newly diagnosed multiple myeloma: Development and validation of a risk score prognostic model.Frontiers in oncology · 2023Article
- Transthyretin V142I Genetic Variant and Cardiac Remodeling, Injury, and Heart Failure Risk in Black Adults.JACC. Heart failure · 2022Article
- Prognostic Significance of Echocardiographic Measures of Cardiac Remodeling in the Community.Current cardiology reports · 2021Review
- Associations of adiponectin and leptin with brain natriuretic peptide in African Americans: the Jackson Heart Study.Cardiovascular endocrinology & metabolism · 2020Article
- Life-Course Cumulative Burden of Body Mass Index and Blood Pressure on Progression of Left Ventricular Mass and Geometry in Midlife: The Bogalusa Heart Study.Circulation research · 2020Article
- Prevalence and Clinical Correlates of Left Ventricular Hypertrophy in Black Africans.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2018Article
- Residential distance to major roadways and cardiac structure in African Americans: cross-sectional results from the Jackson Heart Study.Environmental health : a global access science source · 2017Article
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundThough left ventricular mass (LVM) predicts cardiovascular events (CVD) and mortality in African Americans, limited data exists on factors contributing to change in LVM and its prognostic significance. We hypothesized that baseline blood pressure (BP) and body mass index (BMI) and change in these variables over time are associated with longitudinal increases in LVM and that such increase is associated with greater incidence of CVD. METHODS AND
resultsWe investigated the clinical correlates of change in standardized logarithmically transformed-LVM indexed to height2.7 (log-LVMI) and its association with incident CVD in 606 African Americans (mean age 58±6 years, 66% women) who attended serial examinations 8 years apart. Log-LVMI and clinical covariates were standardized within sex to obtain z scores for both visits. Standardized log-LVMI was modeled using linear regression (correlates of change in standardized log-LVMI) and Cox proportional hazards regression (incidence of CVD [defined as coronary heart disease, stroke, heart failure and intermittent claudication]). Baseline clinical correlates (standardized log-LVM, BMI, systolic BP) and change in systolic BP over time were significantly associated with 8-year change in standardized log-LVMI. In prospective analysis, change in standardized LVM was significantly (P=0.0011) associated with incident CVD (hazards ratio per unit standard deviation change log-LVMI 1.51, 95% CI 1.18 to 1.93).
conclusionsIn our community-based sample of African Americans, baseline BMI and BP, and change in BP on follow-up were key determinants of increase in standardized log-LVMI, which in turn carried an adverse prognosis, underscoring the need for greater control of BP and weight in this group.
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