ArticleScientific reports2015
Ranking the impact of human health disorders on gut metabolism: systemic lupus erythematosus and obesity as study cases.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Microbial dysbiosis in systemic lupus erythematosus: a scientometric study.Frontiers in microbiology · 2024Pooled it
- Association between systemic lupus erythematosus and disruption of gut microbiota: a meta-analysis.Lupus science & medicine · 2022Pooled it
- Trial
- Decoding the gut microbiota-immune dialogue: from bidirectional axis to therapeutic applications.Journal of nanobiotechnology · 2026Review
- Possible Role of Dysbiosis of the Gut Microbiome in SLE.Current rheumatology reports · 2023Review
- Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma.Frontiers in immunology · 2023Review
- Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside.Frontiers of medicine · 2022Review
- Targeting the gut and tumor microbiota in cancer.Nature medicine · 2022Review
- Effect of Zanthoxylum bungeanum essential oil on rumen enzyme activity, microbiome, and metabolites in lambs.PloS one · 2022Article
- The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?Journal of experimental & clinical cancer research : CR · 2021Review
- Correlation Analysis between Gut Microbiota and Metabolites in Children with Systemic Lupus Erythematosus.Journal of immunology research · 2021Article
- Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice.Science translational medicine · 2020Article
- Immunometabolism in the pathogenesis of systemic lupus erythematosus.Journal of translational autoimmunity · 2020Review
- Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line.Nature communications · 2019Article
- Metabolism at the centre of the host-microbe relationship.Clinical and experimental immunology · 2019Review
- Update on the Gastrointestinal Microbiome in Systemic Sclerosis.Current rheumatology reports · 2018Review
- Complementary Methodologies To Investigate Human Gut Microbiota in Host Health, Working towards Integrative Systems Biology.Journal of bacteriology · 2018Review
- Metagenomics Biomarkers Selected for Prediction of Three Different Diseases in Chinese Population.BioMed research international · 2018Article
- Review: Metabolic Control of Immune System Activation in Rheumatic Diseases.Arthritis & rheumatology (Hoboken, N.J.) · 2017Review
- Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile?The FEBS journal · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple factors have been shown to alter intestinal microbial diversity. It remains to be seen, however, how multiple collective pressures impact the activity in the gut environment and which, if any, is positioned as a dominant driving factor determining the final metabolic outcomes. Here, we describe the results of a metabolome-wide scan of gut microbiota in 18 subjects with systemic lupus erythematosus (SLE) and 17 healthy control subjects and demonstrate a statistically significant difference (p < 0.05) between the two groups. Healthy controls could be categorized (p < 0.05) based on their body mass index (BMI), whereas individuals with SLE could not. We discuss the prevalence of SLE compared with BMI as the dominant factor that regulates gastrointestinal microbial metabolism and provide plausible explanatory causes. Our results uncover novel perspectives with clinical relevance for human biology. In particular, we rank the importance of various pathophysiologies for gut homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.